Next Article in Journal
Comparative Investigation of Antimicrobial and Antioxidant Effects of the Extracts from the Inflorescences and Leaves of the Cannabis sativa L. cv. strawberry
Next Article in Special Issue
Zinc Protoporphyrin-9 Potentiates the Anticancer Activity of Dihydroartemisinin
Previous Article in Journal
Inside the Mechanism of Action of Three Pyrazole Derivatives in Human Platelets and Endothelial Cells
Previous Article in Special Issue
New Insights into the Gut Microbiota in Neurodegenerative Diseases from the Perspective of Redox Homeostasis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antioxidants
Volume 12
Issue 2
10.3390/antiox12020217
antioxidants-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Aging-Associated Thyroid Dysfunction Contributes to Oxidative Stress and Worsened Functional Outcomes Following Traumatic Brain Injury

by
Cheng-Ta Hsieh
1,2,3,†,
Ting-Lin Yen
4,5,†,
Yu-Hao Chen
6,7,8,
Jing-Shiun Jan
4,
Ruei-Dun Teng
4,
Chih-Hao Yang
4 and
Jui-Ming Sun
7,8,*
1
Division of Neurosurgery, Department of Surgery, Sijhih Cathay General Hospital, New Taipei City 22174, Taiwan
2
School of Medicine, National Tsing Hua University, Hsinchu 300044, Taiwan
3
Department of Medicine, School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan
4
Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, No. 250, Wu Hsing St., Taipei 110, Taiwan
5
Department of Medical Research, Cathay General Hospital, Taipei 22174, Taiwan
6
Chung-Jen Junior College of Nursing, Health Sciences and Management, Chia-Yi City 62241, Taiwan
7
Section of Neurosurgery, Department of Surgery, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chia-Yi City 600, Taiwan
8
Department of Biotechnology, Asia University, Taichung City 41354, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2023, 12(2), 217; https://doi.org/10.3390/antiox12020217
Submission received: 21 December 2022 / Revised: 10 January 2023 / Accepted: 12 January 2023 / Published: 17 January 2023
(This article belongs to the Special Issue Redox Regulation and Proteostasis in Ageing and Associated Diseases)
Browse Figures
Versions Notes

Abstract

The incidence of traumatic brain injury (TBI) increases dramatically with advanced age and accumulating evidence indicates that age is one of the important predictors of an unfavorable prognosis after brain trauma. Unfortunately, thus far, evidence-based effective therapeutics for geriatric TBI is limited. By using middle-aged animals, we first confirm that there is an age-related change in TBI susceptibility manifested by increased inflammatory events, neuronal death and impaired functional outcomes in motor and cognitive behaviors. Since thyroid hormones function as endogenous regulators of oxidative stress, we postulate that age-related thyroid dysfunction could be a crucial pathology in the increased TBI severity. By surgically removing the thyroid glands, which recapitulates the age-related increase in TBI-susceptible phenotypes, we provide direct evidence showing that endogenous thyroid hormone-dependent compensatory regulation of antioxidant events modulates individual TBI susceptibility, which is abolished in aged or thyroidectomized individuals. The antioxidant capacity of melatonin is well-known, and we found acute melatonin treatment but not liothyronine (T3) supplementation improved the TBI-susceptible phenotypes of oxidative stress, excitotoxic neuronal loss and promotes functional recovery in the aged individuals with thyroid dysfunction. Our study suggests that monitoring thyroid function and acute administration of melatonin could be feasible therapeutics in the management of geriatric-TBI in clinic.
Keywords: traumatic brain injury; aging; oxidative stress; melatonin; thyroid dysfunction traumatic brain injury; aging; oxidative stress; melatonin; thyroid dysfunction
Graphical Abstract

Share and Cite

MDPI and ACS Style

Hsieh, C.-T.; Yen, T.-L.; Chen, Y.-H.; Jan, J.-S.; Teng, R.-D.; Yang, C.-H.; Sun, J.-M. Aging-Associated Thyroid Dysfunction Contributes to Oxidative Stress and Worsened Functional Outcomes Following Traumatic Brain Injury. Antioxidants 2023, 12, 217. https://doi.org/10.3390/antiox12020217

AMA Style

Hsieh C-T, Yen T-L, Chen Y-H, Jan J-S, Teng R-D, Yang C-H, Sun J-M. Aging-Associated Thyroid Dysfunction Contributes to Oxidative Stress and Worsened Functional Outcomes Following Traumatic Brain Injury. Antioxidants. 2023; 12(2):217. https://doi.org/10.3390/antiox12020217

Chicago/Turabian Style

Hsieh, Cheng-Ta, Ting-Lin Yen, Yu-Hao Chen, Jing-Shiun Jan, Ruei-Dun Teng, Chih-Hao Yang, and Jui-Ming Sun. 2023. "Aging-Associated Thyroid Dysfunction Contributes to Oxidative Stress and Worsened Functional Outcomes Following Traumatic Brain Injury" Antioxidants 12, no. 2: 217. https://doi.org/10.3390/antiox12020217

APA Style

Hsieh, C.-T., Yen, T.-L., Chen, Y.-H., Jan, J.-S., Teng, R.-D., Yang, C.-H., & Sun, J.-M. (2023). Aging-Associated Thyroid Dysfunction Contributes to Oxidative Stress and Worsened Functional Outcomes Following Traumatic Brain Injury. Antioxidants, 12(2), 217. https://doi.org/10.3390/antiox12020217

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop