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Antioxidants
Volume 12
Issue 10
10.3390/antiox12101841
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Article

Sargassum horneri Extract Attenuates Depressive-like Behaviors in Mice Treated with Stress Hormone

by
Inhye Park
1,2,†,
Jiwoo Kim
1,†,
Minji Kim
1,2,
Dong Wook Lim
1,
Jonghoon Jung
1,
Min Jung Kim
1,
Junho Song
3,
Suengmok Cho
3 and
Min Young Um
1,2,*
1
Division of Functional Food Research, Korea Food Research Institute, Wanju 55365, Republic of Korea
2
Division of Food Biotechnology, University of Science & Technology, Daejeon 34113, Republic of Korea
3
Department of Food Science and Technology, Institute of Food Science, Pukyong National University, Busan 48513, Republic of Korea
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2023, 12(10), 1841; https://doi.org/10.3390/antiox12101841
Submission received: 1 September 2023 / Revised: 6 October 2023 / Accepted: 9 October 2023 / Published: 10 October 2023
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
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Abstract

Sargassum horneri, a brown seaweed, is known for its various health benefits; however, there are no reports on its effects on depression. This study aimed to investigate the antidepressant effects of S. horneri ethanol extract (SHE) in mice injected with corticosterone (CORT) and to elucidate the underlying molecular mechanisms. Behavioral tests were conducted, and corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and CORT levels were measured. A fluorometric monoamine oxidase (MAO) enzyme inhibition assay was performed. Neurotransmitters like serotonin, dopamine, and norepinephrine levels were determined. Moreover, the ERK-CREB-BDNF signaling pathway in the prefrontal cortex and hippocampus was evaluated. Behavioral tests revealed that SHE has antidepressant effects by reducing immobility time and increasing time spent in open arms. Serum CRH, ACTH, and CORT levels decreased in the mice treated with SHE, as did the glucocorticoid-receptor expression in their brain tissues. SHE inhibited MAO-A and MAO-B activities. In addition, SHE increased levels of neurotransmitters. Furthermore, SHE activated the ERK-CREB-BDNF pathway in the prefrontal cortex and hippocampus. These findings suggest that SHE has antidepressant effects in CORT-injected mice, via the regulation of the hypothalamic-pituitary-adrenal axis and monoaminergic pathway, and through activation of the ERK-CREB-BDNF signaling pathway. Thus, our study suggests that SHE may act as a natural antidepressant.
Keywords: depression; corticosterone; ERK-CREB-BDNF; HPA axis; neurotransmitter; Sargassum horneri depression; corticosterone; ERK-CREB-BDNF; HPA axis; neurotransmitter; Sargassum horneri
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MDPI and ACS Style

Park, I.; Kim, J.; Kim, M.; Lim, D.W.; Jung, J.; Kim, M.J.; Song, J.; Cho, S.; Um, M.Y. Sargassum horneri Extract Attenuates Depressive-like Behaviors in Mice Treated with Stress Hormone. Antioxidants 2023, 12, 1841. https://doi.org/10.3390/antiox12101841

AMA Style

Park I, Kim J, Kim M, Lim DW, Jung J, Kim MJ, Song J, Cho S, Um MY. Sargassum horneri Extract Attenuates Depressive-like Behaviors in Mice Treated with Stress Hormone. Antioxidants. 2023; 12(10):1841. https://doi.org/10.3390/antiox12101841

Chicago/Turabian Style

Park, Inhye, Jiwoo Kim, Minji Kim, Dong Wook Lim, Jonghoon Jung, Min Jung Kim, Junho Song, Suengmok Cho, and Min Young Um. 2023. "Sargassum horneri Extract Attenuates Depressive-like Behaviors in Mice Treated with Stress Hormone" Antioxidants 12, no. 10: 1841. https://doi.org/10.3390/antiox12101841

APA Style

Park, I., Kim, J., Kim, M., Lim, D. W., Jung, J., Kim, M. J., Song, J., Cho, S., & Um, M. Y. (2023). Sargassum horneri Extract Attenuates Depressive-like Behaviors in Mice Treated with Stress Hormone. Antioxidants, 12(10), 1841. https://doi.org/10.3390/antiox12101841

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