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Antioxidants
Volume 11
Issue 7
10.3390/antiox11071380
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Article

Changes in Biomarkers of Redox Status in Saliva of Pigs after an Experimental Sepsis Induction

by
María José López-Martínez
1,
Damián Escribano
1,2,
Alba Ortín-Bustillo
1,
Lorena Franco-Martínez
1,
Luis Guillermo González-Arostegui
1,
José Joaquín Cerón
1 and
Camila Peres Rubio
3,*
1
Interdisciplinary Laboratory of Clinical Analysis, Interlab-UMU, Regional Campus of International Excellence “Mare Nostrum”, University of Murcia, 30100 Murcia, Spain
2
Department of Animal Production, Regional Campus of International Excellence “Mare Nostrum”, University of Murcia, 30100 Murcia, Spain
3
Department of Animal and Food Science, School of Veterinary Science, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2022, 11(7), 1380; https://doi.org/10.3390/antiox11071380
Submission received: 10 June 2022 / Revised: 7 July 2022 / Accepted: 14 July 2022 / Published: 16 July 2022
(This article belongs to the Special Issue Development and Validation of Methods for Analysis of Oxidative Stress in Humans and Animals)
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Abstract

Saliva from pigs is gaining attention as an easy sample to obtain, being a source of biomarkers that can provide information on animal health and welfare. This study aimed to evaluate the changes that can occur in salivary biomarkers of the redox status of pigs with an experimentally induced sepsis. For that, the cupric reducing antioxidant capacity (CUPRAC), ferric reducing ability of saliva (FRAS), Trolox equivalent antioxidant capacity (TEAC), advanced oxidation protein products (AOPP), ferrous oxidation-xylenol orange (FOX), peroxide activity (POX-Act), and reactive oxygen-derived compounds (d-ROMs) were measured in the saliva of pigs with experimentally induced sepsis by endotoxin lipopolysaccharide (LPS), non-septic inflammation induced by turpentine, and in healthy individuals before and after 3 h, 6 h, 24 h, and 48 h. AOPP, POX-Act, and d-ROMs in the sepsis group were higher than in the control from 3 h to 24 h after the inoculation. CUPRAC, FRAS, and TEAC were higher in sepsis than the control group at 24 h. These changes were of higher magnitude than those that occurred in the turpentine group. In conclusion, our findings reveal that sepsis produces changes in salivary biomarkers of redox status, which opens the possibility of using them as potential biomarkers in this species.
Keywords: antioxidants; cupric; ferric; inflammation; oxidative stress; peroxides antioxidants; cupric; ferric; inflammation; oxidative stress; peroxides

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MDPI and ACS Style

López-Martínez, M.J.; Escribano, D.; Ortín-Bustillo, A.; Franco-Martínez, L.; González-Arostegui, L.G.; Cerón, J.J.; Rubio, C.P. Changes in Biomarkers of Redox Status in Saliva of Pigs after an Experimental Sepsis Induction. Antioxidants 2022, 11, 1380. https://doi.org/10.3390/antiox11071380

AMA Style

López-Martínez MJ, Escribano D, Ortín-Bustillo A, Franco-Martínez L, González-Arostegui LG, Cerón JJ, Rubio CP. Changes in Biomarkers of Redox Status in Saliva of Pigs after an Experimental Sepsis Induction. Antioxidants. 2022; 11(7):1380. https://doi.org/10.3390/antiox11071380

Chicago/Turabian Style

López-Martínez, María José, Damián Escribano, Alba Ortín-Bustillo, Lorena Franco-Martínez, Luis Guillermo González-Arostegui, José Joaquín Cerón, and Camila Peres Rubio. 2022. "Changes in Biomarkers of Redox Status in Saliva of Pigs after an Experimental Sepsis Induction" Antioxidants 11, no. 7: 1380. https://doi.org/10.3390/antiox11071380

APA Style

López-Martínez, M. J., Escribano, D., Ortín-Bustillo, A., Franco-Martínez, L., González-Arostegui, L. G., Cerón, J. J., & Rubio, C. P. (2022). Changes in Biomarkers of Redox Status in Saliva of Pigs after an Experimental Sepsis Induction. Antioxidants, 11(7), 1380. https://doi.org/10.3390/antiox11071380

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