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Article

Dietary Parsley Seed Mitigates Methomyl-Induced Impaired Growth Performance, Hemato-Immune Suppression, Oxidative Stress, Hepato-Renal Damage, and Pseudomonas aeruginosa Susceptibility in Oreochromis niloticus

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Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
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Department of Clinical Pathology, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh 13736, Egypt
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National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan 430070, China
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Department of Microbiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
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Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
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Department of Biochemistry, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41511, Egypt
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Department of Biology, Turabah University College, Taif University, Taif 21995, Saudi Arabia
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Clinical Laboratory Sciences Department, Turabah University College, Taif University, Taif 21995, Saudi Arabia
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Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt
*
Authors to whom correspondence should be addressed.
Academic Editor: Evangelos Zoidis
Antioxidants 2022, 11(6), 1185; https://doi.org/10.3390/antiox11061185
Received: 2 June 2022 / Revised: 13 June 2022 / Accepted: 14 June 2022 / Published: 16 June 2022
The present experiment investigated the potential protective role of parsley (Petroselinum crispum) seed meal (PSM) in alleviating methomyl (MET)-adverse impacts on growth, whole-body composition, hematological indicators, hepatorenal function, immune response, oxidative status, and disease resistance to Pseudomonas aeruginosa. For this purpose, 225 healthy Nile tilapia (Oreochromis niloticus) were allotted into five groups (45 fish/group in triplicate). One group was reared in clean water and fed a non-supplemented basal diet, while the other groups were exposed to 20.39 μg L−1 MET and fed a non-fortified basal diet or basal diets supplemented with 0.5, 1.0, or 2.0% of PSM for 60 days. The obtained data revealed significantly lower weight gain, feed intake, and specific growth rate, but higher feed conversion ratio and decreases in crude protein, lipid, and ash contents in the MET-exposed fish. Anemia, leukopenia, lymphocytopenia, and esonipenia were also obvious. Furthermore, MET-exposed fish had significantly higher serum levels of hepatic enzymes and renal damage products. Nevertheless, there was a significant depletion of enzymatic and non-enzymatic antioxidants and increased malondialdehyde, myeloperoxidase, and tumor necrosis factor-α levels in MET-exposed fish. The MET exposure significantly depressed lysozyme activity, nitric oxide, complement3, acetylcholinesterase activity, total proteins, globulin, and albumin levels in O. niloticus serum. Furthermore, pathological alterations in the liver and kidney were noted. The relative percentage of survival rate in MET-exposed fish was dramatically reduced on day 14 post-challenge with P. aeruginosa. The inclusion of PSM, on the other hand, greatly alleviated most of the MET-related negative effects. Taken together, the dietary intervention with PSM has a promising role in alleviating MET-deleterious impacts, rendering parsley seeds a viable aqua feed additive for O. niloticus. View Full-Text
Keywords: methomyl; parsley seed meal; oxidative stress; Oreochromis niloticus; histopathological alterations; disease resistance; immune response; liver; kidney; growth methomyl; parsley seed meal; oxidative stress; Oreochromis niloticus; histopathological alterations; disease resistance; immune response; liver; kidney; growth
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MDPI and ACS Style

El-Houseiny, W.; Algharib, S.A.; Mohamed, E.A.A.; Metwally, M.M.M.; Mahmoud, Y.K.; Alghamdi, Y.S.; Soliman, M.M.; Abd-Elhakim, Y.M.; El-Murr, A.E. Dietary Parsley Seed Mitigates Methomyl-Induced Impaired Growth Performance, Hemato-Immune Suppression, Oxidative Stress, Hepato-Renal Damage, and Pseudomonas aeruginosa Susceptibility in Oreochromis niloticus. Antioxidants 2022, 11, 1185. https://doi.org/10.3390/antiox11061185

AMA Style

El-Houseiny W, Algharib SA, Mohamed EAA, Metwally MMM, Mahmoud YK, Alghamdi YS, Soliman MM, Abd-Elhakim YM, El-Murr AE. Dietary Parsley Seed Mitigates Methomyl-Induced Impaired Growth Performance, Hemato-Immune Suppression, Oxidative Stress, Hepato-Renal Damage, and Pseudomonas aeruginosa Susceptibility in Oreochromis niloticus. Antioxidants. 2022; 11(6):1185. https://doi.org/10.3390/antiox11061185

Chicago/Turabian Style

El-Houseiny, Walaa, Samah Attia Algharib, Eman A. A. Mohamed, Mohamed M. M. Metwally, Yasmina K. Mahmoud, Youssef S. Alghamdi, Mohamed Mohamed Soliman, Yasmina M. Abd-Elhakim, and Abd Elhakeem El-Murr. 2022. "Dietary Parsley Seed Mitigates Methomyl-Induced Impaired Growth Performance, Hemato-Immune Suppression, Oxidative Stress, Hepato-Renal Damage, and Pseudomonas aeruginosa Susceptibility in Oreochromis niloticus" Antioxidants 11, no. 6: 1185. https://doi.org/10.3390/antiox11061185

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