Next Article in Journal
The Pressing Issue of Micro- and Nanoplastic Contamination: Profiling the Reproductive Alterations Mediated by Oxidative Stress
Next Article in Special Issue
Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in the Treatment of Neurological Disorders
Previous Article in Journal
Prophylactic and Ameliorative Effects of PPAR-γ Agonist Pioglitazone in Improving Oxidative Stress, Germ Cell Apoptosis and Inflammation in Gentamycin-Induced Testicular Damage in Adult Male Albino Rats
Previous Article in Special Issue
(−)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial
Review

Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging

by * and *
Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Ana L. Santos
Antioxidants 2022, 11(2), 192; https://doi.org/10.3390/antiox11020192
Received: 19 November 2021 / Revised: 15 January 2022 / Accepted: 16 January 2022 / Published: 19 January 2022
(This article belongs to the Special Issue ROS in Aging and Age-Related Disease)
Peroxisomes are key regulators of cellular and metabolic homeostasis. These organelles play important roles in redox metabolism, the oxidation of very-long-chain fatty acids (VLCFAs), and the biosynthesis of ether phospholipids. Given the essential role of peroxisomes in cellular homeostasis, peroxisomal dysfunction has been linked to various pathological conditions, tissue functional decline, and aging. In the past few decades, a variety of cellular signaling and metabolic changes have been reported to be associated with defective peroxisomes, suggesting that many cellular processes and functions depend on peroxisomes. Peroxisomes communicate with other subcellular organelles, such as the nucleus, mitochondria, endoplasmic reticulum (ER), and lysosomes. These inter-organelle communications are highly linked to the key mechanisms by which cells surveil defective peroxisomes and mount adaptive responses to protect them from damages. In this review, we highlight the major cellular changes that accompany peroxisomal dysfunction and peroxisomal inter-organelle communication through membrane contact sites, metabolic signaling, and retrograde signaling. We also discuss the age-related decline of peroxisomal protein import and its role in animal aging and age-related diseases. Unlike other organelle stress response pathways, such as the unfolded protein response (UPR) in the ER and mitochondria, the cellular signaling pathways that mediate stress responses to malfunctioning peroxisomes have not been systematically studied and investigated. Here, we coin these signaling pathways as “peroxisomal stress response pathways”. Understanding peroxisomal stress response pathways and how peroxisomes communicate with other organelles are important and emerging areas of peroxisome research. View Full-Text
Keywords: peroxisome; reactive oxygen species; acetyl-CoA; plasmalogen; ER stress; mitochondrial dysfunction; apoptosis; pexophagy peroxisome; reactive oxygen species; acetyl-CoA; plasmalogen; ER stress; mitochondrial dysfunction; apoptosis; pexophagy
Show Figures

Figure 1

MDPI and ACS Style

Kim, J.; Bai, H. Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging. Antioxidants 2022, 11, 192. https://doi.org/10.3390/antiox11020192

AMA Style

Kim J, Bai H. Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging. Antioxidants. 2022; 11(2):192. https://doi.org/10.3390/antiox11020192

Chicago/Turabian Style

Kim, Jinoh, and Hua Bai. 2022. "Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging" Antioxidants 11, no. 2: 192. https://doi.org/10.3390/antiox11020192

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop