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Article

(−)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial

1
Department of Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul 02841, Korea
2
Department of Food Science and Biotechnology, Dongguk University, Goyang 10326, Korea
3
Department of Food Science and Technology, Chung-Ang University, Anseong 17546, Korea
4
Animal Center and Preclinical Evaluation Research Institute, Yonam College, Cheonan 31005, Korea
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R&D Center, BTC Corporation, Ansan 15588, Korea
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Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Korea
7
Transdisciplinary Major in Learning Health Systems, Department of Healthcare Sciences, Graduate School, Korea University, Seoul 02841, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Academic Editor: Ana L. Santos
Antioxidants 2021, 10(7), 1026; https://doi.org/10.3390/antiox10071026
Received: 7 May 2021 / Revised: 21 June 2021 / Accepted: 23 June 2021 / Published: 25 June 2021
(This article belongs to the Special Issue ROS in Aging and Age-Related Disease)
Loss of skeletal muscle mass and function with age represents an important source of frailty and functional decline in the elderly. Antioxidants from botanical extracts have been shown to enhance the development, mass, and strength of skeletal muscle by influencing age-related cellular and molecular processes. Tannase-treated green tea extract contains high levels of the antioxidants (−)-epicatechin (EC) and gallic acid that may have therapeutic benefits for age-related muscle decline. The aim of this study was to investigate the effect of tannase-treated green tea extract on various muscle-related parameters, without concomitant exercise, in a single-center, randomized, double-blind, placebo-controlled study. Administration of tannase-treated green tea extract (600 mg/day) for 12 weeks significantly increased isokinetic flexor muscle and handgrip strength in the treatment group compared with those in the placebo (control) group. In addition, the control group showed a significant decrease in arm muscle mass after 12 weeks, whereas no significant change was observed in the treatment group. Blood serum levels of follistatin, myostatin, high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-8, insulin-like growth factor-1 (IGF-1), and cortisol were analyzed, and the decrease in myostatin resulting from the administration of tannase-treated green tea extract was found to be related to the change in muscle mass and strength. In summary, oral administration of tannase-treated green tea extract containing antioxidants without concomitant exercise can improve muscle mass and strength and may have therapeutic benefits in age-related muscle function decline. View Full-Text
Keywords: green tea; tannase; (−)-epicatechin; gallic acid; antioxidants; skeletal muscle green tea; tannase; (−)-epicatechin; gallic acid; antioxidants; skeletal muscle
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MDPI and ACS Style

Seo, H.; Lee, S.-H.; Park, Y.; Lee, H.-S.; Hong, J.S.; Lim, C.Y.; Kim, D.H.; Park, S.-S.; Suh, H.J.; Hong, K.-B. (−)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial. Antioxidants 2021, 10, 1026. https://doi.org/10.3390/antiox10071026

AMA Style

Seo H, Lee S-H, Park Y, Lee H-S, Hong JS, Lim CY, Kim DH, Park S-S, Suh HJ, Hong K-B. (−)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial. Antioxidants. 2021; 10(7):1026. https://doi.org/10.3390/antiox10071026

Chicago/Turabian Style

Seo, Hyeyeong, Seok-Hee Lee, Yooheon Park, Hee-Seok Lee, Jeong S. Hong, Cho Y. Lim, Dong H. Kim, Sung-Soo Park, Hyung J. Suh, and Ki-Bae Hong. 2021. "(−)-Epicatechin-Enriched Extract from Camellia sinensis Improves Regulation of Muscle Mass and Function: Results from a Randomized Controlled Trial" Antioxidants 10, no. 7: 1026. https://doi.org/10.3390/antiox10071026

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