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Review

Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients

1
Department of Pediatrics, Taoyuan Armed Forces General Hospital, Taoyuan City 325, Taiwan
2
Department of Pediatrics, Taoyuan Armed Forces General Hospital Hsinchu Branch, Hsinchu City 300, Taiwan
3
Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
4
Department of Internal Medicine, Division of Nephrology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
5
Department and Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 114, Taiwan
6
School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei 112, Taiwan
7
Department of Medical Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan
8
Division of Nephrology, Department of Medicine, Fu Jen Catholic University Hospital, School of Medicine, Fu Jen Catholic University, New Taipei 24352, Taiwan
9
Division of Infectious Diseases, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan
10
Division of Infectious Diseases, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
11
Division of Nephrology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 231, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Giovanna Mobbili, Roberta Galeazzi and Dario Rusciano
Antioxidants 2021, 10(9), 1440; https://doi.org/10.3390/antiox10091440
Received: 17 July 2021 / Revised: 17 August 2021 / Accepted: 6 September 2021 / Published: 9 September 2021
(This article belongs to the Special Issue The Role of Anti-inflammatory/Antioxidant Intervention in COVID-19)
The coronavirus disease 2019 (COVID-19) pandemic continues to burden healthcare systems worldwide. COVID-19 symptoms are highly heterogeneous, and the patient may be asymptomatic or may present with mild to severe or fatal symptoms. Factors, such as age, sex, and comorbidities, are key determinants of illness severity and progression. Aging is accompanied by multiple deficiencies in interferon production by dendritic cells or macrophages in response to viral infections, resulting in dysregulation of inflammatory immune responses and excess oxidative stress. Age-related dysregulation of immune function may cause a more obvious pathophysiological response to SARS-CoV-2 infection in elderly patients and may accelerate the risk of biological aging, even after recovery. For more favorable treatment outcomes, inhibiting viral replication and dampening inflammatory and oxidative responses before induction of an overt cytokine storm is crucial. Resveratrol is a potent antioxidant with antiviral activity. Herein, we describe the reasons for impaired interferon production, owing to aging, and the impact of aging on innate and adaptive immune responses to infection, which leads to inflammation distress and immunosuppression, thereby causing fulminant disease. Additionally, the molecular mechanism by which resveratrol could reverse a state of excessive basal inflammatory and oxidative stress and low antiviral immunity is discussed. View Full-Text
Keywords: adaptive immunity; aging; antioxidants; inflammation; innate immunity; oxidative stress; resveratrol; SARS-CoV-2 adaptive immunity; aging; antioxidants; inflammation; innate immunity; oxidative stress; resveratrol; SARS-CoV-2
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MDPI and ACS Style

Liao, M.-T.; Wu, C.-C.; Wu, S.-F.V.; Lee, M.-C.; Hu, W.-C.; Tsai, K.-W.; Yang, C.-H.; Lu, C.-L.; Chiu, S.-K.; Lu, K.-C. Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients. Antioxidants 2021, 10, 1440. https://doi.org/10.3390/antiox10091440

AMA Style

Liao M-T, Wu C-C, Wu S-FV, Lee M-C, Hu W-C, Tsai K-W, Yang C-H, Lu C-L, Chiu S-K, Lu K-C. Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients. Antioxidants. 2021; 10(9):1440. https://doi.org/10.3390/antiox10091440

Chicago/Turabian Style

Liao, Min-Tser, Chia-Chao Wu, Shu-Fang Vivienne Wu, Mei-Chen Lee, Wan-Chung Hu, Kuo-Wang Tsai, Chung-Hsiang Yang, Chien-Lin Lu, Sheng-Kang Chiu, and Kuo-Cheng Lu. 2021. "Resveratrol as an Adjunctive Therapy for Excessive Oxidative Stress in Aging COVID-19 Patients" Antioxidants 10, no. 9: 1440. https://doi.org/10.3390/antiox10091440

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