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Article

The Efficacy of Antioxidant Oral Supplements on the Progression of COVID-19 in Non-Critically Ill Patients: A Randomized Controlled Trial

1
Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11362, Saudi Arabia
2
Prince Mohamed Bin Abdulaziz Hospital, Riyadh 14214, Saudi Arabia
3
Clinical Nutrition Department, King Saud University Medical City, Riyadh 11472, Saudi Arabia
4
College of Food Sciences and Agriculture, King Saud University, Riyadh 11362, Saudi Arabia
*
Author to whom correspondence should be addressed.
These authors equally contributed to this work.
Academic Editors: Giovanna Mobbili, Roberta Galeazzi and Dario Rusciano
Antioxidants 2021, 10(5), 804; https://doi.org/10.3390/antiox10050804
Received: 15 April 2021 / Revised: 7 May 2021 / Accepted: 17 May 2021 / Published: 19 May 2021
(This article belongs to the Special Issue The Role of Anti-inflammatory/Antioxidant Intervention in COVID-19)
Modulation of cytokine production using immunonutrition is a relatively novel concept to improve outcomes among patients with SARS-CoV-2 infection and is now hypothesized to help manage COVID-19, however, clinical evidence is lacking. This prospective, double-blinded, randomized parallel-controlled interventional clinical trial investigated the effect of antioxidant supplements on inflammatory cytokines and disease progression in non-critically ill patients. A total of 87 hospitalized COVID-19 patients were randomized using computer-generated-randomization into the supplement group (n = 18) and the placebo group (n = 16) for 10 days. Baseline and final nutritional screening via nutrition risk screening (NRS-2002) and subjective global assessment (SGA), as well as the recording of anthropometric, clinical, biochemical, and functional parameters, were done. Serum ferritin level, cytokine storm parameters such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein 1(MCP-1), C-reactive protein, total leukocyte count, lymphocytic count, and neutrophil-to-lymphocyte ratio were measured. Anthropometric and clinical parameters showed nonsignificant differences between groups. The hematology profile showed improvement in lymphocyte count in the supplement group. However, levels of alkaline phosphatase, IL-6, TNF-α, and MCP-1 were significantly lower in the supplement group. In conclusion, antioxidant oral supplementation significantly reduced the cytokine storm and led to partial improvements in clinical parameters among patients with non-critical COVID-19. View Full-Text
Keywords: COVID-19; antioxidants; cytokine storm; non-critically ill COVID-19; antioxidants; cytokine storm; non-critically ill
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MDPI and ACS Style

Abulmeaty, M.M.A.; Aljuraiban, G.S.; Shaikh, S.M.; ALEid, N.E.; Mazrou, L.R.A.; Turjoman, A.A.; Aldosari, M.S.; Razak, S.; El-Sayed, M.M.; Areabi, T.M.; Alsalafi, R.M.; Al-Helio, Y.S.; Almutairy, A.B.; Molla, H.N. The Efficacy of Antioxidant Oral Supplements on the Progression of COVID-19 in Non-Critically Ill Patients: A Randomized Controlled Trial. Antioxidants 2021, 10, 804. https://doi.org/10.3390/antiox10050804

AMA Style

Abulmeaty MMA, Aljuraiban GS, Shaikh SM, ALEid NE, Mazrou LRA, Turjoman AA, Aldosari MS, Razak S, El-Sayed MM, Areabi TM, Alsalafi RM, Al-Helio YS, Almutairy AB, Molla HN. The Efficacy of Antioxidant Oral Supplements on the Progression of COVID-19 in Non-Critically Ill Patients: A Randomized Controlled Trial. Antioxidants. 2021; 10(5):804. https://doi.org/10.3390/antiox10050804

Chicago/Turabian Style

Abulmeaty, Mahmoud M. A., Ghadeer S. Aljuraiban, Sumaya M. Shaikh, Naif E. ALEid, Lulwa R. Al Mazrou, Abdullah A. Turjoman, Mona S. Aldosari, Suhail Razak, Mervat M. El-Sayed, Tahani M. Areabi, Rokia M. Alsalafi, Yasser S. Al-Helio, Abdulrhman B. Almutairy, and Haneen N. Molla. 2021. "The Efficacy of Antioxidant Oral Supplements on the Progression of COVID-19 in Non-Critically Ill Patients: A Randomized Controlled Trial" Antioxidants 10, no. 5: 804. https://doi.org/10.3390/antiox10050804

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