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Beneficial Role of Antioxidant Secondary Metabolites from Medicinal Plants in Maintaining Oral Health
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Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer

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School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India
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Chemical and Biochemical Processing Division, ICAR—Central Institute for Research on Cotton Technology, Mumbai 400019, India
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School of Mechanical and Civil Engineering, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India
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School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan 173229, India
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Department of Food, Nutrition, & Packaging Sciences, Clemson University, Clemson, SC 29634, USA
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Division of Horticulture, RCSM College of Agriculture, Kolhapur 416004, India
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Dr. S.S. Bhatnagar University Institute of Chemical Engineering and Technology, Panjab University, Chandigarh 160014, India
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Department of Postharvest Technology, Horticultural College and Research Institute, Periyakulam 625604, India
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Department of Food Science and Technology, Dr. Y.S. Parmar University of Horticulture and Forestry, Nauni 173230, India
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Sri Shankara Cancer Hospital and Research Centre, Bengaluru 560004, India
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Division of Crop Physiology, Biochemistry and Post-Harvest Technology, ICAR-Central Potato Research Institute, Shimla 171001, India
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Division of Biochemistry, ICAR—Indian Agricultural Research Institute, New Delhi 110012, India
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Department of Rural Development and Agricultural Extension, College of Agriculture, Wolaita Sodo University, Wolaita Sodo, SNNPR, Ethiopia
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Division of Agricultural Chemicals, ICAR—Indian Agricultural Research Institute, New Delhi 110012, India
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Division of Biochemistry, Sri Karan Narendra Agriculture University, Jobner 303329, India
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Department of Vegetable Science, Tamil Nadu Agricultural University, Coimbatore 641003, India
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Department of Tech. Biosciences, Digianalix, South Samaj Street, Tharpakhna, Ranchi 834001, India
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Pharmacy Program, Department of Phamaceutical Sciences, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia
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Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
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ICAR—National Research Centre for Orchids, Pakyong 737106, India
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Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata 700073, India
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Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-748 Olsztyn, Poland
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Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrecht’s University, 24105 Kiel, Germany
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Authors to whom correspondence should be addressed.
Academic Editor: Ron Mittler
Antioxidants 2021, 10(9), 1358; https://doi.org/10.3390/antiox10091358
Received: 17 July 2021 / Revised: 19 August 2021 / Accepted: 21 August 2021 / Published: 26 August 2021
(This article belongs to the Special Issue Natural Antioxidants and Oral Health)
Oral cancer continues to be a leading cause of death worldwide, and its prevalence is particularly high in developing countries, where people chew tobacco and betel nut on a regular basis. Radiation-, chemo-, targeted-, immuno-, and hormone-based therapies along with surgery are commonly used as part of a treatment plan. However, these treatments frequently result in various unwanted short- to long-term side effects. As a result, there is an urgent need to develop treatment options for oral cancer that have little or no adverse effects. Numerous bioactive compounds derived from various plants have recently attracted attention as therapeutic options for cancer treatment. Antioxidants found in medicinal plants, such as vitamins E, C, and A, reduce damage to the mucosa by neutralizing free radicals found in various oral mucosal lesions. Phytochemicals found in medicinal plants have the potential to modulate cellular signalling pathways that alter the cellular defence mechanisms to protect normal cells from reactive oxygen species (ROS) and induce apoptosis in cancer cells. This review aims to provide a comprehensive overview of various medicinal plants and phytoconstituents that have shown the potential to be used as oral cancer therapeutics. View Full-Text
Keywords: oral cancer; phytoconstituents; medicinal plants; oral squamous cell carcinoma oral cancer; phytoconstituents; medicinal plants; oral squamous cell carcinoma
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Figure 1

MDPI and ACS Style

Prakash, S.; Radha; Kumar, M.; Kumari, N.; Thakur, M.; Rathour, S.; Pundir, A.; Sharma, A.K.; Bangar, S.P.; Dhumal, S.; Singh, S.; Thiyagarajan, A.; Sharma, A.; Sharma, M.; Changan, S.; Sasi, M.; Senapathy, M.; Pradhan, P.C.; Garg, N.K.; Ilakiya, T.; Nitin, M.; Abdel-Daim, M.M.; Puri, S.; Natta, S.; Dey, A.; Amarowicz, R.; Mekhemar, M. Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer. Antioxidants 2021, 10, 1358. https://doi.org/10.3390/antiox10091358

AMA Style

Prakash S, Radha, Kumar M, Kumari N, Thakur M, Rathour S, Pundir A, Sharma AK, Bangar SP, Dhumal S, Singh S, Thiyagarajan A, Sharma A, Sharma M, Changan S, Sasi M, Senapathy M, Pradhan PC, Garg NK, Ilakiya T, Nitin M, Abdel-Daim MM, Puri S, Natta S, Dey A, Amarowicz R, Mekhemar M. Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer. Antioxidants. 2021; 10(9):1358. https://doi.org/10.3390/antiox10091358

Chicago/Turabian Style

Prakash, Suraj, Radha, Manoj Kumar, Neeraj Kumari, Mamta Thakur, Sonia Rathour, Ashok Pundir, Abhishek K. Sharma, Sneh P. Bangar, Sangram Dhumal, Surinder Singh, Anitha Thiyagarajan, Anshu Sharma, Munisha Sharma, Sushil Changan, Minnu Sasi, Marisennayya Senapathy, Prakash C. Pradhan, Nitin K. Garg, Tamilselvan Ilakiya, Mukesh Nitin, Mohamed M. Abdel-Daim, Sunil Puri, Suman Natta, Abhijit Dey, Ryszard Amarowicz, and Mohamed Mekhemar. 2021. "Plant-Based Antioxidant Extracts and Compounds in the Management of Oral Cancer" Antioxidants 10, no. 9: 1358. https://doi.org/10.3390/antiox10091358

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