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Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation

1
Obesity Unit, Department of Medical Sciences and Public Health, University of Cagliari, Ospedale San Giovanni di Dio, Via Ospedale 54, 09124 Cagliari, Italy
2
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
3
Microbiology and Virology Unit, Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Gianluca Rizzo and Mauro Lombardo
Antioxidants 2021, 10(5), 708; https://doi.org/10.3390/antiox10050708
Received: 30 March 2021 / Revised: 23 April 2021 / Accepted: 25 April 2021 / Published: 29 April 2021
(This article belongs to the Special Issue Plant-Based Diets and Their Antioxidant Role in Human Health)
It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related disorders. In this scenario, oxidative stress plays a pivotal role. Evidence suggests that the global dietary patterns may represent a tool in counteracting oxidative stress, thus preventing the onset of diseases related to oxidative stress. More specifically, dietary patterns based on the regular consumption of fruits and vegetables (i.e., Mediterranean diet) have been licensed by various national nutritional guidelines in many countries for their health-promoting effects. Such patterns, indeed, result in being rich in specific components, such as fiber, minerals, vitamins and antioxidants, whose beneficial effects on human health have been widely reported. This suggests a potential nutraceutical power of specific dietary components. In this manuscript, we summarize the most relevant evidence reporting the impact of dietary antioxidants on gut microbiota composition, inflammation and obesity, and we underline that antioxidants are implicated in a complex interplay between gut microbiota, inflammation and obesity, thus suggesting their possible role in the development and modulation of chronic diseases related to oxidative stress and in the maintenance of wellness. Do all roads lead to Rome? View Full-Text
Keywords: inflammation; obesity; gut microbiota; oxidative stress; antioxidants; polyphenols; ageing; nutraceutical inflammation; obesity; gut microbiota; oxidative stress; antioxidants; polyphenols; ageing; nutraceutical
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MDPI and ACS Style

Deledda, A.; Annunziata, G.; Tenore, G.C.; Palmas, V.; Manzin, A.; Velluzzi, F. Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation. Antioxidants 2021, 10, 708. https://doi.org/10.3390/antiox10050708

AMA Style

Deledda A, Annunziata G, Tenore GC, Palmas V, Manzin A, Velluzzi F. Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation. Antioxidants. 2021; 10(5):708. https://doi.org/10.3390/antiox10050708

Chicago/Turabian Style

Deledda, Andrea, Giuseppe Annunziata, Gian C. Tenore, Vanessa Palmas, Aldo Manzin, and Fernanda Velluzzi. 2021. "Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation" Antioxidants 10, no. 5: 708. https://doi.org/10.3390/antiox10050708

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