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Article

Antioxidant and Anti-Inflammaging Ability of Prune (Prunus Spinosa L.) Extract Result in Improved Wound Healing Efficacy

1
Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy
2
Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostic, Heinrich Heine University and the IUF- Leibniz Research Institute for Environmental Medicine Auf’m Hennekamp 50, 40225 Düsseldorf, Germany
3
Center for Nanofibers and Nanotechnology, National University of Singapore, Singapore 119077, Singapore
*
Author to whom correspondence should be addressed.
equally contributed.
equally contributed.
Academic Editor: Dorothy Klimis-Zacas
Antioxidants 2021, 10(3), 374; https://doi.org/10.3390/antiox10030374
Received: 5 February 2021 / Revised: 19 February 2021 / Accepted: 23 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue Antioxidants and Biomaterials in Health and Nutrition)
Prunus spinosa L. fruit (PSF) ethanol extract, showing a peculiar content of biologically active molecules (polyphenols), was investigated for its wound healing capacity, a typical feature that declines during aging and is negatively affected by the persistence of inflammation and oxidative stress. To this aim, first, PSF anti-inflammatory properties were tested on young and senescent LPS-treated human umbilical vein endothelial cells (HUVECs). As a result, PSF treatment increased miR-146a and decreased IRAK-1 and IL-6 expression levels. In addition, the PSF antioxidant effect was validated in vitro with DPPH assay and confirmed by in vivo treatments in C. elegans. Our findings showed beneficial effects on worms’ lifespan and healthspan with positive outcomes on longevity markers (i.e., miR-124 upregulation and miR-39 downregulation) as well. The PSF effect on wound healing was tested using the same cells and experimental conditions employed to investigate PSF antioxidant and anti-inflammaging ability. PSF treatment resulted in a significant improvement of wound healing closure (ca. 70%), through cell migration, both in young and older cells, associated to a downregulation of inflammation markers. In conclusion, PSF extract antioxidant and anti-inflammaging abilities result in improved wound healing capacity, thus suggesting that PSF might be helpful to improve the quality of life for its beneficial health effects. View Full-Text
Keywords: polyphenols; MicroRNA; HUVEC; lifespan; C. elegans; tissue regeneration; cell migration; aging phenotype; biological aging polyphenols; MicroRNA; HUVEC; lifespan; C. elegans; tissue regeneration; cell migration; aging phenotype; biological aging
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MDPI and ACS Style

Coppari, S.; Colomba, M.; Fraternale, D.; Brinkmann, V.; Romeo, M.; Rocchi, M.B.L.; Di Giacomo, B.; Mari, M.; Guidi, L.; Ramakrishna, S.; Ventura, N.; Albertini, M.C. Antioxidant and Anti-Inflammaging Ability of Prune (Prunus Spinosa L.) Extract Result in Improved Wound Healing Efficacy. Antioxidants 2021, 10, 374. https://doi.org/10.3390/antiox10030374

AMA Style

Coppari S, Colomba M, Fraternale D, Brinkmann V, Romeo M, Rocchi MBL, Di Giacomo B, Mari M, Guidi L, Ramakrishna S, Ventura N, Albertini MC. Antioxidant and Anti-Inflammaging Ability of Prune (Prunus Spinosa L.) Extract Result in Improved Wound Healing Efficacy. Antioxidants. 2021; 10(3):374. https://doi.org/10.3390/antiox10030374

Chicago/Turabian Style

Coppari, Sofia, Mariastella Colomba, Daniele Fraternale, Vanessa Brinkmann, Margherita Romeo, Marco B.L. Rocchi, Barbara Di Giacomo, Michele Mari, Loretta Guidi, Seeram Ramakrishna, Natascia Ventura, and Maria C. Albertini 2021. "Antioxidant and Anti-Inflammaging Ability of Prune (Prunus Spinosa L.) Extract Result in Improved Wound Healing Efficacy" Antioxidants 10, no. 3: 374. https://doi.org/10.3390/antiox10030374

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