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Open AccessCase Report

Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report

Department of Neuropsychiatry, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, Japan
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Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(11), 292; https://doi.org/10.3390/brainsci9110292
Received: 18 September 2019 / Revised: 21 October 2019 / Accepted: 24 October 2019 / Published: 25 October 2019
(This article belongs to the Collection Collection on Clinical Neuroscience)
Carbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and fecal/urine incontinence, after remission of acute CO poisoning. Furthermore, he showed confusion, with disorientation in terms of time and space. All symptoms, including cognitive impairment, were dramatically improved by amantadine monotherapy. The present case illustrates the possibility of amantadine treatment for cognitive impairment as well as Parkinsonism induced by CO poisoning. View Full-Text
Keywords: amantadine; carbon monoxide poisoning; delayed neuropsychiatric sequelae; NMDA-R antagonist amantadine; carbon monoxide poisoning; delayed neuropsychiatric sequelae; NMDA-R antagonist
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Nakano, T.; Hasegawa, T.; Suzuki, D.; Motomura, E.; Okada, M. Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report. Brain Sci. 2019, 9, 292.

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