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The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease

1
Department of Psychiatry, College of Medicine, Haeundae Paik Hospital, Inje University, Busan 47392, Korea
2
Paik Institute for Clinical Research, Department of Health Science and Technology, Graduate School, Inje University, Busan 47392, Korea
3
Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea
4
Department of Convergence Biomedical Science, College of Medicine, Inje University, Busan 47392, Korea
5
Department of Biochemistry, College of Medicine, Inje University, Busan 47392, Korea
6
Paik Institute for Clinical Research, Inje University, Busan 47392, Korea
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(10), 285; https://doi.org/10.3390/brainsci9100285
Received: 16 September 2019 / Revised: 18 October 2019 / Accepted: 19 October 2019 / Published: 21 October 2019
(This article belongs to the Special Issue Neurogenesis and Gliogenesis in Health and Disease)
Melatonin is a hormone that is secreted by the pineal gland. To date, melatonin is known to regulate the sleep cycle by controlling the circadian rhythm. However, recent advances in neuroscience and molecular biology have led to the discovery of new actions and effects of melatonin. In recent studies, melatonin was shown to have antioxidant activity and, possibly, to affect the development of Alzheimer’s disease (AD). In addition, melatonin has neuroprotective effects and affects neuroplasticity, thus indicating potential antidepressant properties. In the present review, the new functions of melatonin are summarized and a therapeutic target for the development of new drugs based on the mechanism of action of melatonin is proposed. View Full-Text
Keywords: melatonin; oxydative stress; antioxidant; neuroprotective effect; antidepressant melatonin; oxydative stress; antioxidant; neuroprotective effect; antidepressant
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Lee, J.G.; Woo, Y.S.; Park, S.W.; Seog, D.-H.; Seo, M.K.; Bahk, W.-M. The Neuroprotective Effects of Melatonin: Possible Role in the Pathophysiology of Neuropsychiatric Disease. Brain Sci. 2019, 9, 285.

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