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Open AccessArticle

Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus

1
Department of Psychiatry and Psychotherapy, University Hospital of Cologne, Medical faculty, 50937 Cologne, Germany
2
Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich, 52428 Jülich, Germany
3
Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany
4
Department of Neurology, University Hospital of Cologne, Medical faculty, 50937 Cologne, Germany
5
Johanniter Hospital Oberhausen, Department of Psychiatry, Psychotherapy and Psychosomatics, 46145 Oberhausen, Germany
6
Department of Stereotactic and Functional Neurosurgery, University of Cologne, 50937 Cologne, Germany
7
Department of Neurology, Charité-University Medicine (CVK), 10117 Berlin, Germany
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(10), 264; https://doi.org/10.3390/brainsci9100264
Received: 11 September 2019 / Accepted: 30 September 2019 / Published: 3 October 2019
Weight changes are insufficiently understood adverse events of deep brain stimulation. In this context, exploring neural networks of weight control may inform novel treatment strategies for weight-related disorders. In this study, we investigated weight changes after deep brain stimulation of the ventral striatum/ventral capsule and to what extent changes are associated with connectivity to feeding-related networks. We retrospectively analyzed 25 patients undergoing deep brain stimulation for obsessive-compulsive disorder or substance dependency. Weight changes were assessed preoperatively and six to twelve months after surgery and then matched with individual stimulation sites and stimulation-dependent functional connectivity to a priori defined regions of interest that are involved in food intake. We observed a significant weight gain after six to twelve months of continuous stimulation. Weight increases were associated with medial/apical localization of stimulation sites and with connectivity to hypothalamic areas and the bed nucleus. Thus, deep brain stimulation of the ventral striatum/ventral capsule influences weight depending on localization and connectivity of stimulation sites. Bearing in mind the significance of weight-related disorders, we advocate further prospective studies investigating the neuroanatomical and neuropsychological underpinnings of food intake and their neuromodulatory therapeutic potential. View Full-Text
Keywords: deep brain stimulation; DBS; weight; food intake; bed nucleus of the stria terminalis; obesity; obsessive-compulsive disorder; addiction deep brain stimulation; DBS; weight; food intake; bed nucleus of the stria terminalis; obesity; obsessive-compulsive disorder; addiction
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Baldermann, J.C.; Hahn, L.; Dembek, T.A.; Kohl, S.; Kuhn, J.; Visser-Vandewalle, V.; Horn, A.; Huys, D. Weight Change after Striatal/Capsule Deep Brain Stimulation Relates to Connectivity to the Bed Nucleus of the Stria Terminalis and Hypothalamus. Brain Sci. 2019, 9, 264.

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