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Open AccessArticle

Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study

1
Department of Neurosurgery, University Hospital Basel, 4031 Basel, Switzerland
2
Cerebrovascular Research Group, Department of BioMedical Research, University of Bern, 3008 Bern, Switzerland
3
Department of Neurosurgery, Neurocenter of Southern Switzerland, Regional Hospital Lugano, 6900 Lugano, Switzerland
4
Department of Neurosurgery, Kantonsspital Aarau, 5001 Aarau, Switzerland
5
Department of Biomedical Research, University of Bern, 3008 Bern, Switzerland
6
Department of Neurosurgery, Bern University Hospital, Inselspital Bern, 3008 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(10), 249; https://doi.org/10.3390/brainsci9100249
Received: 6 August 2019 / Revised: 20 September 2019 / Accepted: 23 September 2019 / Published: 24 September 2019
Background: The inflammatory pathway in cerebrospinal fluid (CSF) leads to delayed cerebral vasospasm (DCVS) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). The role of IL-1α has never been evaluated in a rabbit SAH model. The aim of our study is to analyze systemic and CSF changes of IL-1α, and to evaluate potential associations with the onset of DCVS in a rabbit closed cranium SAH model. Methods: 17 New Zealand white rabbits were randomized into two groups, SAH (n = 12) and sham (n = 5). In the first group, SAH was induced by extracranial-intracranial shunting from the subclavian artery into the cerebral cistern of magna under intracranial pressure (ICP) monitoring. The sham group served as a control. The CSF and blood samples for IL-1α measurement were taken at day zero before SAH induction and at day three. Results: There was a significant increase of ICP (p = 0.00009) and a decrease of cerebral perfusion pressure (CPP) (p = 0.00089) during SAH induction. At follow up, there was a significant increase of systemic IL-1α in the SAH as compared with the sham group (p = 0.042). There was no statistically significant difference in the CSF values in both groups. The CSF IL-1α values showed a correlation trend of DCVS. Conclusions: Systemic IL-1α levels are elevated after SAH induction in a rabbit SAH model. View Full-Text
Keywords: subarachnoid hemorrhage; IL-1α; inflammation; animal model subarachnoid hemorrhage; IL-1α; inflammation; animal model
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Croci, D.M.; Wanderer, S.; Strange, F.; Grüter, B.E.; Casoni, D.; Sivanrupan, S.; Widmer, H.R.; Di Santo, S.; Fandino, J.; Mariani, L.; Marbacher, S. Systemic and CSF Interleukin-1α Expression in a Rabbit Closed Cranium Subarachnoid Hemorrhage Model: An Exploratory Study. Brain Sci. 2019, 9, 249.

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