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Brain Sci. 2018, 8(7), 117; https://doi.org/10.3390/brainsci8070117

Pallidal Stimulation Modulates Pedunculopontine Nuclei in Parkinson’s Disease

1
Department of Neurology, Otto-von-Guericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
2
Center for Behavioural Brain Sciences, Otto-von-Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany
3
Department of Behavioural Neurology, Leibniz Institute of Neurobiology, Brenneckestr. 6, 39120 Magdeburg, Germany
4
Department of Stereotactic Neurosurgery, Otto-von-Guericke University, Leipziger Street 44, 39120 Magdeburg, Germany
5
German Centre for Neurodegenerative Diseases, Otto-von-Guericke University, Leipziger Street 44, 39120 Magdeburg, Germany
6
NEUROLOGY MOVES, Academic Neurological Practice, Bismarckstrasse 45-47, 10627 Berlin, Germany
C.K. and I.G. contributed equally to this work as first authors.
A.K. and H.H. contributed equally to this work as senior authors.
*
Author to whom correspondence should be addressed.
Received: 9 May 2018 / Revised: 18 June 2018 / Accepted: 22 June 2018 / Published: 25 June 2018
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Abstract

Background: In advanced Parkinson’s disease, the pedunculopontine nucleus region is thought to be abnormally inhibited by gamma-aminobutyric acid (GABA) ergic inputs from the over-active globus pallidus internus. Recent attempts to boost pedunculopontine nucleus function through deep brain stimulation are promising, but suffer from the incomplete understanding of the physiology of the pedunculopontine nucleus region. Methods: Local field potentials of the pedunculopontine nucleus region and the globus pallidus internus were recorded and quantitatively analyzed in a patient with Parkinson’s disease. In particular, we compared the local field potentials from the pedunculopontine nucleus region at rest and during deep brain stimulation of the globus pallidus internus. Results: At rest, the spectrum of local field potentials in the globus pallidus internus was mainly characterized by delta-theta and beta frequency activity whereas the spectrum of the pedunculopontine nucleus region was dominated by activity only in the delta and theta band. High-frequency deep brain stimulation of the globus pallidus internus led to increased theta activity in the pedunculopontine nucleus region and enabled information exchange between the left and right pedunculopontine nuclei. Therefore, Conclusions: When applying deep brain stimulation in the globus pallidus internus, its modulatory effect on pedunculopontine nucleus physiology should be taken into account. View Full-Text
Keywords: deep brain stimulation; pedunculopontine nucleus; globus pallidus internus; Parkinson’s disease; local field potentials deep brain stimulation; pedunculopontine nucleus; globus pallidus internus; Parkinson’s disease; local field potentials
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Galazky, I.; Kluge, C.; Schmitt, F.C.; Kopitzki, K.; Zaehle, T.; Voges, J.; Büntjen, L.; Kupsch, A.; Hinrichs, H. Pallidal Stimulation Modulates Pedunculopontine Nuclei in Parkinson’s Disease. Brain Sci. 2018, 8, 117.

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