Next Article in Journal
A Study on Photostability of Amphetamines and Ketamine in Hair Irradiated under Artificial Sunlight
Next Article in Special Issue
Pallidal Stimulation Modulates Pedunculopontine Nuclei in Parkinson’s Disease
Previous Article in Journal
The Sound of Words Evokes Affective Brain Responses
Previous Article in Special Issue
Frameless Stereotaxis for Subthalamic Nucleus Deep Brain Stimulation: An Innovative Method for the Direct Visualization of Electrode Implantation by Intraoperative X-ray Control
Open AccessReview

Neuromodulatory Treatments for Alcohol Use Disorder: A Review

Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Bldg./R-227, Stanford, CA 94305, USA
Author to whom correspondence should be addressed.
Brain Sci. 2018, 8(6), 95;
Received: 3 April 2018 / Revised: 15 May 2018 / Accepted: 21 May 2018 / Published: 28 May 2018
Alcohol use disorder (AUD) is a prevalent condition characterized by chronic alcohol-seeking behaviors and has become a significant economic burden with global ramifications on public health. While numerous treatment options are available for AUD, many are unable to sustain long-term sobriety. The nucleus accumbens (NAcc) upholds an integral role in mediating reward behavior and has been implicated as a potential target for deep brain stimulation (DBS) in the context of AUD. DBS is empirically thought to disrupt pathological neuronal synchrony, a hallmark of binge behavior. Pre-clinical animal models and pilot human clinical studies utilizing DBS for the treatment of AUD have shown promise for reducing alcohol-related cravings and prolonging abstinence. In this review, we outline the various interventions available for AUD, and the translational potential DBS has to modulate functionality of the NAcc as a treatment for AUD. View Full-Text
Keywords: nucleus accumbens; alcoholism; binge drinking; deep brain stimulation; neuromodulation; mouse models nucleus accumbens; alcoholism; binge drinking; deep brain stimulation; neuromodulation; mouse models
Show Figures

Figure 1

MDPI and ACS Style

Salib, A.-M.N.; Ho, A.L.; Sussman, E.S.; Pendharkar, A.V.; Halpern, C.H. Neuromodulatory Treatments for Alcohol Use Disorder: A Review. Brain Sci. 2018, 8, 95.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop