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Neuromodulatory Treatments for Alcohol Use Disorder: A Review

Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Bldg./R-227, Stanford, CA 94305, USA
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Brain Sci. 2018, 8(6), 95; https://doi.org/10.3390/brainsci8060095
Received: 3 April 2018 / Revised: 15 May 2018 / Accepted: 21 May 2018 / Published: 28 May 2018
Alcohol use disorder (AUD) is a prevalent condition characterized by chronic alcohol-seeking behaviors and has become a significant economic burden with global ramifications on public health. While numerous treatment options are available for AUD, many are unable to sustain long-term sobriety. The nucleus accumbens (NAcc) upholds an integral role in mediating reward behavior and has been implicated as a potential target for deep brain stimulation (DBS) in the context of AUD. DBS is empirically thought to disrupt pathological neuronal synchrony, a hallmark of binge behavior. Pre-clinical animal models and pilot human clinical studies utilizing DBS for the treatment of AUD have shown promise for reducing alcohol-related cravings and prolonging abstinence. In this review, we outline the various interventions available for AUD, and the translational potential DBS has to modulate functionality of the NAcc as a treatment for AUD. View Full-Text
Keywords: nucleus accumbens; alcoholism; binge drinking; deep brain stimulation; neuromodulation; mouse models nucleus accumbens; alcoholism; binge drinking; deep brain stimulation; neuromodulation; mouse models
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Salib, A.-M.N.; Ho, A.L.; Sussman, E.S.; Pendharkar, A.V.; Halpern, C.H. Neuromodulatory Treatments for Alcohol Use Disorder: A Review. Brain Sci. 2018, 8, 95.

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