Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period
by
Clémence Disdier 1
, Xiaodi Chen 1, Jeong-Eun Kim 1, Steven W. Threlkeld 2 and Barbara S. Stonestreet 1,*
Clémence Disdier 1, Xiaodi Chen 1, Jeong-Eun Kim 1, Steven W. Threlkeld 2 and Barbara S. Stonestreet 1,*
1
Department of Pediatrics, Women & Infants Hospital of Rhode Island, The Alpert Medical School of Brown University, Providence, RI 02905, USA
2
Department of Neuroscience, Regis College, Weston, MA 02493, USA
*
Author to whom correspondence should be addressed.
Brain Sci. 2018, 8(6), 101; https://doi.org/10.3390/brainsci8060101
Received: 11 May 2018 / Revised: 31 May 2018 / Accepted: 5 June 2018 / Published: 7 June 2018
(This article belongs to the Special Issue Prevention and Intervention for Neonatal Brain Injury)
Perinatal brain injury is a major cause of morbidity and long-standing disability in newborns. Hypothermia is the only therapy approved to attenuate brain injury in the newborn. However, this treatment is unfortunately only partially neuroprotective and can only be used to treat hypoxic-ischemic encephalopathy in full term infants. Therefore, there is an urgent need for adjunctive therapeutic strategies. Post-ischemic neuro-inflammation is a crucial contributor to the evolution of brain injury in neonates and constitutes a promising therapeutic target. Recently, we demonstrated encouraging neuroprotective capacities of anti-cytokine monoclonal antibodies (mAbs) in an ischemic-reperfusion (I/R) model of brain injury in the ovine fetus. The purpose of this review is to summarize the current knowledge regarding the inflammatory response in the perinatal sheep brain after I/R injury and to review our recent findings regarding the beneficial effects of treatment with anti-cytokine mAbs.
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Keywords:
brain; cytokines; ischemia reperfusion; neuro-inflammation; ovine fetus; monoclonal antibodies
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MDPI and ACS Style
Disdier, C.; Chen, X.; Kim, J.-E.; Threlkeld, S.W.; Stonestreet, B.S. Anti-Cytokine Therapy to Attenuate Ischemic-Reperfusion Associated Brain Injury in the Perinatal Period. Brain Sci. 2018, 8, 101.
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