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Surgical Neurostimulation for Spinal Cord Injury

Academic Neurosurgery Unit, St George’s, University of London, London SW17 0RE, UK
Division of Brain Sciences, Faculty of Medicine, Imperial College London, London W6 8RF, UK
The Miami Project to Cure Paralysis and Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
Author to whom correspondence should be addressed.
Academic Editors: Tipu Aziz and Alex Green
Brain Sci. 2017, 7(2), 18;
Received: 21 December 2016 / Revised: 30 January 2017 / Accepted: 2 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Deep Brain Stimulation (DBS) Applications)
PDF [550 KB, uploaded 10 February 2017]


Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI. We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI. View Full-Text
Keywords: spinal cord injury; spinal cord stimulation; deep brain stimulation; neuromodulation spinal cord injury; spinal cord stimulation; deep brain stimulation; neuromodulation

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Chari, A.; Hentall, I.D.; Papadopoulos, M.C.; Pereira, E.A.C. Surgical Neurostimulation for Spinal Cord Injury. Brain Sci. 2017, 7, 18.

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