Next Article in Journal
Surgical Neurostimulation for Spinal Cord Injury
Next Article in Special Issue
Automaticity and Flexibility of S–R Retrieval During Priming
Previous Article in Journal
NLRP12 Inflammasome Expression in the Rat Brain in Response to LPS during Morphine Tolerance
Previous Article in Special Issue
Spatial Memory Activity Distributions Indicate the Hippocampus Operates in a Continuous Manner
Article Menu

Export Article

Open AccessArticle
Brain Sci. 2017, 7(2), 17;

Spatial Impairment and Memory in Genetic Disorders: Insights from Mouse Models

Center for Mind/Brain Sciences, University of Trento, Rovereto 38068, Italy
Neuroscience and Brain Technologies Department, Istituto Italiano di Tecnologia, Genova 16163, Italy
Author to whom correspondence should be addressed.
Academic Editor: Elizabeth Race
Received: 1 November 2016 / Revised: 15 January 2017 / Accepted: 7 February 2017 / Published: 9 February 2017
(This article belongs to the Special Issue The Mechanisms of Memory in the Brain)
Full-Text   |   PDF [432 KB, uploaded 9 February 2017]   |  


Research across the cognitive and brain sciences has begun to elucidate some of the processes that guide navigation and spatial memory. Boundary geometry and featural landmarks are two distinct classes of environmental cues that have dissociable neural correlates in spatial representation and follow different patterns of learning. Consequently, spatial navigation depends both on the type of cue available and on the type of learning provided. We investigated this interaction between spatial representation and memory by administering two different tasks (working memory, reference memory) using two different environmental cues (rectangular geometry, striped landmark) in mouse models of human genetic disorders: Prader-Willi syndrome (PWScrm+/p− mice, n = 12) and Beta-catenin mutation (Thr653Lys-substituted mice, n = 12). This exploratory study provides suggestive evidence that these models exhibit different abilities and impairments in navigating by boundary geometry and featural landmarks, depending on the type of memory task administered. We discuss these data in light of the specific deficits in cognitive and brain function in these human syndromes and their animal model counterparts. View Full-Text
Keywords: navigation; spatial memory; boundary geometry; feature; Prader-Willi; Beta-catenin gene navigation; spatial memory; boundary geometry; feature; Prader-Willi; Beta-catenin gene

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Lee, S.A.; Tucci, V.; Vallortigara, G. Spatial Impairment and Memory in Genetic Disorders: Insights from Mouse Models. Brain Sci. 2017, 7, 17.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top