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Open AccessReview

Functional and Structural Brain Changes Associated with Methamphetamine Abuse

by Reem K. Jan 1,2,*, Rob R. Kydd 2,3 and Bruce R. Russell 1,2
1
School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
2
Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
3
Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
*
Author to whom correspondence should be addressed.
Brain Sci. 2012, 2(4), 434-482; https://doi.org/10.3390/brainsci2040434
Received: 31 July 2012 / Revised: 11 September 2012 / Accepted: 11 September 2012 / Published: 1 October 2012
(This article belongs to the Special Issue Addiction and Neuroadaptation)
Methamphetamine (MA) is a potent psychostimulant drug whose abuse has become a global epidemic in recent years. Firstly, this review article briefly discusses the epidemiology and clinical pharmacology of methamphetamine dependence. Secondly, the article reviews relevant animal literature modeling methamphetamine dependence and discusses possible mechanisms of methamphetamine-induced neurotoxicity. Thirdly, it provides a critical review of functional and structural neuroimaging studies in human MA abusers; including positron emission tomography (PET) and functional and structural magnetic resonance imaging (MRI). The effect of abstinence from methamphetamine, both short- and long-term within the context of these studies is also reviewed. View Full-Text
Keywords: addiction; cognitive control; decision-making; dopamine; grey matter; functional magnetic resonance imaging; methamphetamine; neurotoxicity; positron emission tomography; serotonin addiction; cognitive control; decision-making; dopamine; grey matter; functional magnetic resonance imaging; methamphetamine; neurotoxicity; positron emission tomography; serotonin
MDPI and ACS Style

Jan, R.K.; Kydd, R.R.; Russell, B.R. Functional and Structural Brain Changes Associated with Methamphetamine Abuse. Brain Sci. 2012, 2, 434-482.

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