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Brief Report

Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study

Department of Psychiatry and Addiction Center, University of Michigan, 4250 Plymouth Road, Ann Arbor, MI 48109, USA
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Author to whom correspondence should be addressed.
Academic Editor: Iliyan S. Ivanov
Brain Sci. 2022, 12(7), 913; https://doi.org/10.3390/brainsci12070913
Received: 10 June 2022 / Revised: 6 July 2022 / Accepted: 9 July 2022 / Published: 13 July 2022
Having a family history of alcohol use problems (FH+) conveys risk for alcohol use in offspring. Reward-related brain functioning may play a role in this vulnerability. The present study investigated brain function in the nucleus accumbens (NAcc) associated with the anticipation of reward in youth with two biological parents with alcohol use problems (FH+2), one biological parent with alcohol use problems (FH+1), and no biological parents with alcohol use problems (FH-). Participants were from the large, national Adolescent Brain Cognitive Development (ABCD) Study (mean age: 9.93; 48% female; FH+2 n = 223, FH+1 n = 1447, FH- n = 9690) and the Michigan Longitudinal Study (MLS), consisting of community-recruited families with high rates of alcohol use disorder (mean age: 10.54; 39.3% female; FH+2 n = 40, FH+1 n = 51, FH- n = 40). Reward anticipation was measured by the monetary incentive delay task. Regression models were used to assess associations between FH status and the anticipation of large rewards in right and left NAcc regions of interest. In both studies, FH+2 youth showed blunted anticipatory reward responding in the right NAcc compared to FH+1 youth. In the MLS, FH+2 youth also had blunted anticipatory reward responding in the right NAcc compared to the FH- group. Convergent results across two separate samples provide insights into a unique vulnerability of FH+2 youth and suggest that binary FH+ versus FH- categorizations may obscure important differences within FH+ youth. View Full-Text
Keywords: fMRI; reward; nucleus accumbens; family history; alcohol; MID task fMRI; reward; nucleus accumbens; family history; alcohol; MID task
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MDPI and ACS Style

Martz, M.E.; Hardee, J.E.; Cope, L.M.; McCurry, K.L.; Soules, M.; Zucker, R.A.; Heitzeg, M.M. Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study. Brain Sci. 2022, 12, 913. https://doi.org/10.3390/brainsci12070913

AMA Style

Martz ME, Hardee JE, Cope LM, McCurry KL, Soules M, Zucker RA, Heitzeg MM. Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study. Brain Sciences. 2022; 12(7):913. https://doi.org/10.3390/brainsci12070913

Chicago/Turabian Style

Martz, Meghan E., Jillian E. Hardee, Lora M. Cope, Katherine L. McCurry, Mary Soules, Robert A. Zucker, and Mary M. Heitzeg. 2022. "Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study® and Michigan Longitudinal Study" Brain Sciences 12, no. 7: 913. https://doi.org/10.3390/brainsci12070913

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