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Review

Factors Related to Hemifacial Spasm Recurrence in Patients Undergoing Microvascular Decompression—A Systematic Review and Meta-Analysis

1
Department of Neuroscience, Neurosurgery Section, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
2
Department of Neurosurgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas M. Kinfe
Brain Sci. 2022, 12(5), 583; https://doi.org/10.3390/brainsci12050583
Received: 29 March 2022 / Revised: 26 April 2022 / Accepted: 28 April 2022 / Published: 29 April 2022
There is a lack of knowledge about the factors associated with the recurrence of hemifacial spam (HFS) following an initially successful microvascular decompression (MVD) surgery. The aim of the present study was to systematically review the pertinent literature and carry out a meta-analysis of factors linked to HFS recurrence in patients undergoing initially successful MVD treatment. An online literature search was launched on the PubMed/Medline and Scopus databases. The following data were collected: sex, age at surgery, affected side, reported improvement after surgery, presence of post-operatory facial weakness, symptom duration, offender vessels, and data obtained from intraoperative neurophysiological monitoring. Upon full-text review, eight articles were included, studying 1105 patients, of which 64 (5.7%) reported recurrence after MVD surgery for hemifacial spasm. There was a statistically significant increased incidence of HFS recurrence in patients with the persistence of lateral spread response (LSR after surgery (OR 9.44 (95% CI 1.69–52.58) p 0.01), while those patients experiencing a shorter disease duration before going to surgery were significantly less prone to experiencing disease recurrence (OR 0.11 (95% CI 0.03–0.46) p 0.002). The remaining examined factors did not result as significantly associated with the risk of recurrence. The funnel plots were largely symmetrical for each variable studied. Taken together, the results of our meta-analysis seem to suggest that short-term symptom duration is a protective factor against HFS recurrence after MVD surgery, while LSR persistence is a negative prognostic factor. Well-designed randomized controlled clinical trials with a long follow-up are expected to further explore therapeutic alternatives for HFS recurrence. View Full-Text
Keywords: hemifacial spasm recurrence; microvascular decompression; lateral spread response hemifacial spasm recurrence; microvascular decompression; lateral spread response
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MDPI and ACS Style

Menna, G.; Battistelli, M.; Rapisarda, A.; Izzo, A.; D’Ercole, M.; Olivi, A.; Montano, N. Factors Related to Hemifacial Spasm Recurrence in Patients Undergoing Microvascular Decompression—A Systematic Review and Meta-Analysis. Brain Sci. 2022, 12, 583. https://doi.org/10.3390/brainsci12050583

AMA Style

Menna G, Battistelli M, Rapisarda A, Izzo A, D’Ercole M, Olivi A, Montano N. Factors Related to Hemifacial Spasm Recurrence in Patients Undergoing Microvascular Decompression—A Systematic Review and Meta-Analysis. Brain Sciences. 2022; 12(5):583. https://doi.org/10.3390/brainsci12050583

Chicago/Turabian Style

Menna, Grazia, Marco Battistelli, Alessandro Rapisarda, Alessandro Izzo, Manuela D’Ercole, Alessandro Olivi, and Nicola Montano. 2022. "Factors Related to Hemifacial Spasm Recurrence in Patients Undergoing Microvascular Decompression—A Systematic Review and Meta-Analysis" Brain Sciences 12, no. 5: 583. https://doi.org/10.3390/brainsci12050583

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