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Brain Sciences
Volume 12
Issue 2
10.3390/brainsci12020246
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Review

Role of Stress-Related Dopamine Transmission in Building and Maintaining a Protective Cognitive Reserve

by
Simona Cabib
1,2,*,
Claudio Latagliata
1 and
Cristina Orsini
2
1
Department of Experimental Neurosciences, IRCCS Fondazione Santa Lucia, 00179 Roma, Italy
2
Department of Psychology, Sapienza University of Rome, 00185 Roma, Italy
*
Author to whom correspondence should be addressed.
Brain Sci. 2022, 12(2), 246; https://doi.org/10.3390/brainsci12020246
Submission received: 25 January 2022 / Revised: 5 February 2022 / Accepted: 8 February 2022 / Published: 11 February 2022
(This article belongs to the Special Issue The Role of Dopamine in Neural Circuits)
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Abstract

This short review presents the hypothesis that stress-dependent dopamine (DA) transmission contributes to developing and maintaining the brain network supporting a cognitive reserve. Research has shown that people with a greater cognitive reserve are better able to avoid symptoms of degenerative brain changes. The paper will review evidence that: (1) successful adaptation to stressors involves development and stabilization of effective but flexible coping strategies; (2) this process requires dynamic reorganization of functional networks in the adult brain; (3) DA transmission is amongst the principal mediators of this process; (4) age- and disease-dependent cognitive impairment is associated with dysfunctional connectivity both between and within these same networks as well as with reduced DA transmission.
Keywords: avoidance; cognitive reserve; connectivity; controllability; coping; dopamine; large-scale brain networks avoidance; cognitive reserve; connectivity; controllability; coping; dopamine; large-scale brain networks

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MDPI and ACS Style

Cabib, S.; Latagliata, C.; Orsini, C. Role of Stress-Related Dopamine Transmission in Building and Maintaining a Protective Cognitive Reserve. Brain Sci. 2022, 12, 246. https://doi.org/10.3390/brainsci12020246

AMA Style

Cabib S, Latagliata C, Orsini C. Role of Stress-Related Dopamine Transmission in Building and Maintaining a Protective Cognitive Reserve. Brain Sciences. 2022; 12(2):246. https://doi.org/10.3390/brainsci12020246

Chicago/Turabian Style

Cabib, Simona, Claudio Latagliata, and Cristina Orsini. 2022. "Role of Stress-Related Dopamine Transmission in Building and Maintaining a Protective Cognitive Reserve" Brain Sciences 12, no. 2: 246. https://doi.org/10.3390/brainsci12020246

APA Style

Cabib, S., Latagliata, C., & Orsini, C. (2022). Role of Stress-Related Dopamine Transmission in Building and Maintaining a Protective Cognitive Reserve. Brain Sciences, 12(2), 246. https://doi.org/10.3390/brainsci12020246

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