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Volume 12
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Article

Cooperative Parent-Mediated Therapy in Children with Fragile X Syndrome and Williams Beuren Syndrome: A Pilot RCT Study of a Transdiagnostic Intervention-Preliminary Data

by
Paolo Alfieri
1,*,†,
Francesco Scibelli
1,†,
Laura Casula
1,
Simone Piga
2,
Eleonora Napoli
1,
Giovanni Valeri
1 and
Stefano Vicari
1,3
1
Child and Adolescent Psychiatry Unit, Department of Neuroscience, Bambino Gesù Children′s Hospital, IRCCS, 00165 Rome, Italy
2
Clinical Epidemiology, Bambino Gesù Children’s Hospital, IRCCS, 00165 Rome, Italy
3
Department of Life Sciences and Public Health, Catholic University, 00168 Rome, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally.
Brain Sci. 2022, 12(1), 8; https://doi.org/10.3390/brainsci12010008
Submission received: 12 October 2021 / Revised: 5 December 2021 / Accepted: 17 December 2021 / Published: 23 December 2021
(This article belongs to the Special Issue Social Interaction in Children with Neurodevelopmental Disorders)
Review Reports Versions Notes

Abstract

Children with fragile X syndrome and William Beuren syndrome share several socio-communicative deficits. In both populations, around 30/35% of individuals meets criteria for autism spectrum disorder on gold standard instruments. Notwithstanding, few studies have explored feasibility and validity of therapy for socio-communicative deficits in individuals with these genetic conditions. In this study, we present preliminary data on a pilot RCT aimed to verify the effectiveness of cooperative parent-mediated therapy for socio-communicative deficits in a transdiagnostic perspective in a small sample of 12 participants. Our preliminary data showed that the experimental group had significant improvement in one socio-communicative skill (responsivity) and in clinical global impression, while the control group in an adaptive measure of socialization and word production. Implications of these results are then discussed.
Keywords: parent-mediated therapy; RCT; autism spectrum disorders; fragile X syndrome; William Beuren syndrome; transdiagnostic intervention parent-mediated therapy; RCT; autism spectrum disorders; fragile X syndrome; William Beuren syndrome; transdiagnostic intervention

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MDPI and ACS Style

Alfieri, P.; Scibelli, F.; Casula, L.; Piga, S.; Napoli, E.; Valeri, G.; Vicari, S. Cooperative Parent-Mediated Therapy in Children with Fragile X Syndrome and Williams Beuren Syndrome: A Pilot RCT Study of a Transdiagnostic Intervention-Preliminary Data. Brain Sci. 2022, 12, 8. https://doi.org/10.3390/brainsci12010008

AMA Style

Alfieri P, Scibelli F, Casula L, Piga S, Napoli E, Valeri G, Vicari S. Cooperative Parent-Mediated Therapy in Children with Fragile X Syndrome and Williams Beuren Syndrome: A Pilot RCT Study of a Transdiagnostic Intervention-Preliminary Data. Brain Sciences. 2022; 12(1):8. https://doi.org/10.3390/brainsci12010008

Chicago/Turabian Style

Alfieri, Paolo, Francesco Scibelli, Laura Casula, Simone Piga, Eleonora Napoli, Giovanni Valeri, and Stefano Vicari. 2022. "Cooperative Parent-Mediated Therapy in Children with Fragile X Syndrome and Williams Beuren Syndrome: A Pilot RCT Study of a Transdiagnostic Intervention-Preliminary Data" Brain Sciences 12, no. 1: 8. https://doi.org/10.3390/brainsci12010008

APA Style

Alfieri, P., Scibelli, F., Casula, L., Piga, S., Napoli, E., Valeri, G., & Vicari, S. (2022). Cooperative Parent-Mediated Therapy in Children with Fragile X Syndrome and Williams Beuren Syndrome: A Pilot RCT Study of a Transdiagnostic Intervention-Preliminary Data. Brain Sciences, 12(1), 8. https://doi.org/10.3390/brainsci12010008

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