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Article

Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent Model of Autism

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Department of Basic Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
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Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia
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Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia
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Prince Naif for Health Research Center, King Saud University, P.O. Box 7805, Riyadh 11472, Saudi Arabia
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Central Laboratory, Female Center for Medical Studies and Scientific Section, King Saud University, P.O. Box 22452, Riyadh 11472, Saudi Arabia
*
Author to whom correspondence should be addressed.
Authors contributed equally to this work.
Academic Editors: Masaru Tanaka and Lydia Giménez-Llort
Brain Sci. 2021, 11(8), 1038; https://doi.org/10.3390/brainsci11081038
Received: 6 July 2021 / Revised: 3 August 2021 / Accepted: 4 August 2021 / Published: 5 August 2021
Autism is associated with gastrointestinal dysfunction and gut microbiota dysbiosis, including an overall increase in Clostridium. Modulation of the gut microbiota is suggested to improve autistic symptoms. In this study, we explored the implementation of two different interventions that target the microbiota in a rodent model of autism and their effects on social behavior: the levels of different fecal Clostridium spp., and hippocampal transcript levels. Autism was induced in young Sprague Dawley male rats using oral gavage of propionic acid (PPA) for three days, while controls received saline. PPA-treated animals were divided to receive either saline, fecal transplant from healthy donor rats, or Bifidobacterium for 22 days, while controls continued to receive saline. We found that PPA attenuated social interaction in animals, which was rescued by the two interventions. PPA-treated animals had a significantly increased abundance of fecal C. perfringens with a concomitant decrease in Clostridium cluster IV, and exhibited high hippocampal Bdnf expression compared to controls. Fecal microbiota transplantation or Bifidobacterium treatment restored the balance of fecal Clostridium spp. and normalized the level of Bdnf expression. These findings highlight the involvement of the gut–brain axis in the etiology of autism and propose possible interventions in a preclinical model of autism. View Full-Text
Keywords: autism spectrum disorder; microbiota; propionic acid; Clostridium perfringens; Clostridium cluster IV; fecal transplant; Bifidobacterium; hippocampus; BDNF autism spectrum disorder; microbiota; propionic acid; Clostridium perfringens; Clostridium cluster IV; fecal transplant; Bifidobacterium; hippocampus; BDNF
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MDPI and ACS Style

Abuaish, S.; Al-Otaibi, N.M.; Abujamel, T.S.; Alzahrani, S.A.; Alotaibi, S.M.; AlShawakir, Y.A.; Aabed, K.; El-Ansary, A. Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent Model of Autism. Brain Sci. 2021, 11, 1038. https://doi.org/10.3390/brainsci11081038

AMA Style

Abuaish S, Al-Otaibi NM, Abujamel TS, Alzahrani SA, Alotaibi SM, AlShawakir YA, Aabed K, El-Ansary A. Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent Model of Autism. Brain Sciences. 2021; 11(8):1038. https://doi.org/10.3390/brainsci11081038

Chicago/Turabian Style

Abuaish, Sameera, Norah M. Al-Otaibi, Turki S. Abujamel, Saleha A. Alzahrani, Sohailah M. Alotaibi, Yasser A. AlShawakir, Kawther Aabed, and Afaf El-Ansary. 2021. "Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent Model of Autism" Brain Sciences 11, no. 8: 1038. https://doi.org/10.3390/brainsci11081038

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