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Article

Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study

1
Department of Neurology, St. Josef-Hospital, Ruhr-University, D-44791 Bochum, Germany
2
Neurodegeneration Research, Centre for Protein Diagnostics (ProDi), Ruhr-University, D-44791 Bochum, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Sirwan Darweesh
Brain Sci. 2021, 11(7), 879; https://doi.org/10.3390/brainsci11070879
Received: 26 May 2021 / Revised: 24 June 2021 / Accepted: 29 June 2021 / Published: 30 June 2021
(This article belongs to the Special Issue Advances in Parkinsonian Syndromes)
(1) Background: Peripheral nerve involvement is increasingly recognized in Parkinson’s disease (PD). Although non-motor symptoms and postural instability are early features of atypical parkinsonian syndromes (APS), peripheral neuropathies in APS have not been addressed in detail thus far. Therefore, the aim of this study was to investigate the prevalence and characteristics of polyneuropathies (PNP) in multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), as representative syndromes of APS. (2) Methods: In total, 8 MSA and 6 PSP patients were comprehensively analyzed regarding subjective, clinical (motor and non-motor) and paraclinical PNP features using nerve conduction studies and high resolution nerve ultrasounds (HRUS). (3) Results: A total of 87.5% of MSA and 66.7% of PSP patients complained of at least one neuropathic symptom, with electrophysiological confirmation of PNP in 50.0% of both, MSA and PSP patients. PNP symptom severity in PSP and motor nerve amplitude in MSA were associated with compromised motor function. Morphologic nerve examination by HRUS showed few alterations according to the axonal type of PNP. (4) Conclusions: The overall high PNP symptom burden may be partially credited to the significant prevalence of electrophysiologically diagnosed PNP, and impact motor aspects of APS. The findings of this exploratory study reinforce further investigations on a larger scale, in order to elucidate peripheral nerve involvement and the underlying pathophysiological mechanisms of APS. View Full-Text
Keywords: polyneuropathy; atypical parkinsonian syndromes; multiple system atrophy; progressive supranuclear palsy; nerve conduction study polyneuropathy; atypical parkinsonian syndromes; multiple system atrophy; progressive supranuclear palsy; nerve conduction study
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MDPI and ACS Style

Rohmann, R.; Kühn, E.; Scherbaum, R.; Hilker, L.; Kools, S.; Scholz, L.; Müller, K.; Huckemann, S.; Schneider-Gold, C.; Gold, R.; Pitarokoili, K.; Tönges, L.; Kwon, E.H. Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study. Brain Sci. 2021, 11, 879. https://doi.org/10.3390/brainsci11070879

AMA Style

Rohmann R, Kühn E, Scherbaum R, Hilker L, Kools S, Scholz L, Müller K, Huckemann S, Schneider-Gold C, Gold R, Pitarokoili K, Tönges L, Kwon EH. Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study. Brain Sciences. 2021; 11(7):879. https://doi.org/10.3390/brainsci11070879

Chicago/Turabian Style

Rohmann, Rachel, Eva Kühn, Raphael Scherbaum, Lovis Hilker, Saskia Kools, Leonard Scholz, Katharina Müller, Sophie Huckemann, Christiane Schneider-Gold, Ralf Gold, Kalliopi Pitarokoili, Lars Tönges, and Eun H. Kwon. 2021. "Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study" Brain Sciences 11, no. 7: 879. https://doi.org/10.3390/brainsci11070879

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