Recall and Self-Relevance of Emotional Words Predict Subjective Self-Evaluation of Cognition in Patients with MTLE with or without Depressive Symptoms
Abstract
:Highlights
- Depression specific self-relevance bias is observed in MTLE patients with depressive symptoms.
- Behavioral variables are predictors of subjective self-evaluation of cognition.
- Epilepsy duration is a predictor of subjective self-evaluation of cognition.
1. Introduction
1.1. The Presence of Depressive Symptoms
1.2. The Presence of Depression-Specific Cognitive Bias without Current Depressive Symptoms
1.3. The Objective Memory Ability Assessment Method
2. Methods
2.1. Participants
2.2. Experimental Procedure
2.2.1. Inventories
Beck Depression Inventory—II (BDI-II)
Quality of Life in Epilepsy Inventory—31 (QOLIE-31)
2.2.2. Experimental Behavioral Paradigm
Self-Relevance Ratings Task
Experimental Stimuli
2.3. Data Analysis
3. Results
3.1. Self-Evaluation of Cognition in Participants with MTLE
3.2. Task Performance
3.2.1. Overall Free Recall
3.2.2. Self-Relevance Ratings
3.3. Correlation Analysis
3.4. Hierarchical Regression Analysis
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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MTLE Group | MTLE -d | MTLE +d | Control Group | |
---|---|---|---|---|
N = 39 | N = 39 | |||
Sex | ||||
Male | 11 | 8 | 3 | 11 |
Female | 28 | 20 | 8 | 28 |
Age (y) | 35 ± 11 | 33.39 ± 11.77 | 38.18 ± 8.86 | 34.54 ± 11.60 |
Education (y) | 12.7 ± 2.2 | 12.7 ± 2.2 | ||
≤12 | 75.21% | 21 (75.00%) | 8 (72.72%) | 75.21% |
>12 | 24.79% | 7 (25.00%) | 3 (27.27) | 24.79% |
Total BDI score: | 10.32 ± 8.18 | 5.85 ± 3.77 | 21.27 ± 5.00 | 3.82 ± 2.18 |
Seizure focus lateralization: | ||||
Left | 21 (54.85%) | 12 (42.86%) | 6 (54.5%) | |
Right | 18 (46.15%) | 16 (57.14%) | 5 (45.5%) | |
Hippocampal sclerosis | 1 (2.56%) | 0 | 1 (9.1%) | |
Number of seizures/month over past 6 months | 1.54 ± 1.69 | 1.29 ± 1.36 | 2.18 ± 2.32 | |
Epilepsy duration (y) | 15.46 ± 10.81 | 11.89 ± 9.02 | 24.55 ± 9.89 | |
Age at seizure onset (y) | 19.10 ± 12.92 | 21.36 ± 12.57 | 13.36 ± 12.54 | |
AED therapy | ||||
Monotherapy | 56.40% | 16 (57.14%) | 6 (54.5%) | |
Polytherapy | 43.60% | 12 (42.86%) | 5 (45.5%) |
RecWt | Min | Max | M | SEM | SD |
---|---|---|---|---|---|
Control | 1 | 23 | 7.18 | 0.719 | 4.489 |
MTLE -d | 0 | 9 | 3.71 | 0.496 | 2.623 |
MTLE +d | 0 | 5 | 1.73 | 0.506 | 1.679 |
Control | M | SEM | SD |
---|---|---|---|
SRWneg | 1.03 | 0.332 | 2.071 |
SRWp | 11.85 | 0.516 | 3.224 |
SRWneut | 5.49 | 0.367 | 2.293 |
MTLE -d | M | SEM | SD |
SRWneg | 1.11 | 0.229 | 1.188 |
SRWp | 12.70 | 0.592 | 3.074 |
SRWneut | 5.00 | 0.389 | 2.019 |
MTLE +d | M | SEM | SD |
SRWneg | 3.27 | 0.854 | 2.832 |
SRWp | 8.82 | 1.583 | 5.250 |
SRWneut | 6.27 | 0.776 | 2.573 |
F | Ss | p | η2 | |
---|---|---|---|---|
Within-subjects effects | ||||
Emotional word valence | 48.09 | 2/146 | <0.001 | 0.397 |
Emotional word valence × age | 7.16 | 2/146 | <0.001 | 0.089 |
Emotional word valence × group | 5.12 | 4/146 | <0.001 | 0.123 |
Between-subjects effects | ||||
Group | 0.06 | 2/73 | 0.938 | |
Age | 1.42 | 1/73 | 0.238 |
QOLIE CS | Confidence Interval 95% | BDI | Confidence Interval 95% | |
---|---|---|---|---|
RecWt | 0.43 ** | 0.047–0.591 | −0.33 * | −0.455–0.130 |
RecWp | 0.38 * | 0.052–0.577 | −0.27 ′ | −0.311–0.204 |
SRWp | 0.58 ** | 0.125–0.674 | −0.46 ** | −0.574–0.173 |
SRWneg | −0.46 ** | −0.507–0.114 | −0.54 ** | −0.088–0.564 |
SF | −0.33 | −0.514–0.109 | 0.21 | −0.172–0.563 |
ED | −0.62 ** | −0.645–(−0.172) | 0.49 ** | −0.216–0.359 |
ASO | 0.17 | −0.307–0.271 | −0.25 | −0.330–0.270 |
Age | −0.42 * | −0.642–(−0.136) | 0.19 | −0.265–0.301 |
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Preglej, L.; Marinkovic, K.; Hećimović, H. Recall and Self-Relevance of Emotional Words Predict Subjective Self-Evaluation of Cognition in Patients with MTLE with or without Depressive Symptoms. Brain Sci. 2021, 11, 1402. https://doi.org/10.3390/brainsci11111402
Preglej L, Marinkovic K, Hećimović H. Recall and Self-Relevance of Emotional Words Predict Subjective Self-Evaluation of Cognition in Patients with MTLE with or without Depressive Symptoms. Brain Sciences. 2021; 11(11):1402. https://doi.org/10.3390/brainsci11111402
Chicago/Turabian StylePreglej, Lidija, Ksenija Marinkovic, and Hrvoje Hećimović. 2021. "Recall and Self-Relevance of Emotional Words Predict Subjective Self-Evaluation of Cognition in Patients with MTLE with or without Depressive Symptoms" Brain Sciences 11, no. 11: 1402. https://doi.org/10.3390/brainsci11111402