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Review

Can Brain Health Be Supported by Vitamin D-Based Supplements? A Critical Review

Laboratory of Physiology, Department of Translational Medicine, University of Piemonte Orientale, Via Solaroli 17, 28100 Novara, Italy
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Brain Sci. 2020, 10(9), 660; https://doi.org/10.3390/brainsci10090660
Received: 21 July 2020 / Revised: 10 September 2020 / Accepted: 15 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Biomakers of Brain Ageing)
This review presents recent knowledge on the neuroprotective effects of vitamin D and their usefulness as oral supplementation when combined with other molecules, such as curcumin. A critical look at the effectiveness of vitamin D in this field is also provided. Vitamin D plays a crucial role in neuroprotection and in the cognitive decline associated with aging, where vitamin D’s levels are related to the levels of several neurotrophic factors. An important role of vitamin D has also been observed in the mechanism of neuroinflammation, which is the basis of several aging conditions, including cognitive decline and neurodegeration; furthermore, the neuroprotective effect of vitamin D in the cognitive decline of aging has recently been reported. For this reason, many food supplements created for humans contain vitamin D alone or combined with other molecules with antioxidant properties. However, recent studies also explored negative consequences of the use at a high dosage of vitamin D. Vitamin D in tissues or brain cells can also modulate calbindin-D28K, parvalbumin, and calretinin, and is involved in immune function, thanks also to the combination with curcumin. Curcumin acts as a free radical scavenger and antioxidant, inhibiting lipid peroxidation and oxidative DNA damage. In particular, curcumin is a potent immune-regulatory agent and its administration has been reported to attenuate cognitive impairments. These effects could be exploited in the future to control the mechanisms that lead to the brain decay typical of neurodegenerative diseases. View Full-Text
Keywords: vitamin D; brain aging; neurodegenerative diseases; neuroinflammation; VDR vitamin D; brain aging; neurodegenerative diseases; neuroinflammation; VDR
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MDPI and ACS Style

Farghali, M.; Ruga, S.; Morsanuto, V.; Uberti, F. Can Brain Health Be Supported by Vitamin D-Based Supplements? A Critical Review. Brain Sci. 2020, 10, 660. https://doi.org/10.3390/brainsci10090660

AMA Style

Farghali M, Ruga S, Morsanuto V, Uberti F. Can Brain Health Be Supported by Vitamin D-Based Supplements? A Critical Review. Brain Sciences. 2020; 10(9):660. https://doi.org/10.3390/brainsci10090660

Chicago/Turabian Style

Farghali, Mahitab, Sara Ruga, Vera Morsanuto, and Francesca Uberti. 2020. "Can Brain Health Be Supported by Vitamin D-Based Supplements? A Critical Review" Brain Sciences 10, no. 9: 660. https://doi.org/10.3390/brainsci10090660

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