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Open AccessEditorial

Cannabis and Cognition: Connecting the Dots towards the Understanding of the Relationship

Section of Psychiatry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London SE5 8AF, UK
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(3), 133;
Received: 23 February 2020 / Accepted: 25 February 2020 / Published: 27 February 2020
(This article belongs to the Special Issue Cannabis: Neuropsychiatry and Its Effects on Brain and Behavior)
Several studies have advanced the understanding of the effects of cannabis on cognitive function. A comprehensive reappraisal of such literature may help in drawing conclusions about the potential risks associated with cannabis use. In summary, the evidence suggests that earlier age of use, high-frequency and high-potency cannabis use, as well as sustained use over time and use of synthetic cannabinoids, are all correlated with a higher likelihood of developing potentially severe and persistent executive function impairments. While the exact mechanisms underlying the adverse effects of cannabis on cognition are not completely clear, Magnetic Resonance Imaging (MRI) studies support the presence of both structural and functional alterations associated with cannabis use. Cognitive dysfunction is also a core feature of many neuropsychiatric disorders and care must be taken regarding the effects of cannabis use in these patient populations. Cognitive impairments affect patients’ daily functions, sociability, and long-term outcome, posing elevated economic, social, and clinical burdens. There is, thus, a compelling case for implementing behavioral and cognitive rehabilitation therapies for these patients, as well as investigating the endocannabinoid system in the development of new psychopharmacological treatments. View Full-Text
Keywords: delta-9-tetrahydrocannabinol; endocannabinoid system; executive functions delta-9-tetrahydrocannabinol; endocannabinoid system; executive functions
MDPI and ACS Style

Colizzi, M.; Tosato, S.; Ruggeri, M. Cannabis and Cognition: Connecting the Dots towards the Understanding of the Relationship. Brain Sci. 2020, 10, 133.

AMA Style

Colizzi M, Tosato S, Ruggeri M. Cannabis and Cognition: Connecting the Dots towards the Understanding of the Relationship. Brain Sciences. 2020; 10(3):133.

Chicago/Turabian Style

Colizzi, Marco; Tosato, Sarah; Ruggeri, Mirella. 2020. "Cannabis and Cognition: Connecting the Dots towards the Understanding of the Relationship" Brain Sci. 10, no. 3: 133.

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