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Open AccessArticle

Synergistic Effects of Scalp Acupuncture and Repetitive Transcranial Magnetic Stimulation on Cerebral Infarction: A Randomized Controlled Pilot Trial

1
Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, DongShin University, Naju City 58245, Korea
2
Clinical Research Center, DongShin University Gwangju Korean Medicine Hospital, 141, Wolsan-ro, Nam-gu, Gwangju City 61619, Korea
3
Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School and Hospital, Gwangju City 61469, Korea
4
Department of Nursing, Christian College of Nursing, Gwangju City 61662, Korea
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(2), 87; https://doi.org/10.3390/brainsci10020087
Received: 10 January 2020 / Revised: 5 February 2020 / Accepted: 5 February 2020 / Published: 7 February 2020
(This article belongs to the Collection Collection on Clinical Neuroscience)
This study investigated the synergistic effects of scalp acupuncture (SA) and repetitive transcranial magnetic stimulation (rTMS), known to be effective for cerebral infarction. This outcome-assessor-blinded, randomized controlled clinical trial included a per-protocol analysis to compare the efficacy of SA and electromagnetic convergence stimulation (SAEM-CS) and single or no stimulation. The trial was conducted with 42 cerebral infarction patients (control group, 12; SA group, 11; rTMS group, 8; SAEM-CS group, 11). All patient groups underwent two sessions of CSRT per day. SA, rTMS, and SAEM-CS were conducted once per day, 5 days per week, for 3 weeks. The primary outcome was evaluated using the Fugl–Mayer assessment (FMA). FMA Upper Extremity, FMA total, MBI, and FIM scores significantly increased in the rTMS group compared with the control group. Additionally, FMA Upper Extremity, FMA total, MBI and FIM scores significantly increased in the rTMS group compared with the SAEM-CS group. However, there were no significant changes in the SA or SAEM-CS groups. In conclusion, low-frequency rTMS in the contralesional hemisphere may have long-term therapeutic effects on upper extremity motor function recovery and improvements in activities of daily living. SAEM-CS did not show positive synergistic effects of SA and rTMS.
Keywords: cerebral infarction; acupuncture; transcranial magnetic stimulation; randomized controlled trial cerebral infarction; acupuncture; transcranial magnetic stimulation; randomized controlled trial
MDPI and ACS Style

Kim, J.-H.; Han, J.-Y.; Song, M.-K.; Park, G.-C.; Lee, J.-S. Synergistic Effects of Scalp Acupuncture and Repetitive Transcranial Magnetic Stimulation on Cerebral Infarction: A Randomized Controlled Pilot Trial. Brain Sci. 2020, 10, 87.

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