Next Article in Journal
Relationships between Dream and Previous Wake Emotions Assessed through the Italian Modified Differential Emotions Scale
Next Article in Special Issue
Phenomenology, Epidemiology and Aetiology of Postpartum Psychosis: A Review
Previous Article in Journal
Are People with Aphasia (PWA) Involved in the Creation of Quality of Life and Aphasia Impact-Related Questionnaires? A Scoping Review
Previous Article in Special Issue
The 12-Item Self-Rating Questionnaire for Depressive Mixed State (DMX-12) for Screening of Mixed Depression and Mixed Features
 
 
Article

A Naturalistic Study of Youth Referred to a Tertiary Care Facility for Acute Hypomanic or Manic Episode

IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, 56028 Calambrone-Pisa, Italy
*
Author to whom correspondence should be addressed.
Brain Sci. 2020, 10(10), 689; https://doi.org/10.3390/brainsci10100689
Received: 12 August 2020 / Revised: 28 September 2020 / Accepted: 28 September 2020 / Published: 29 September 2020
(This article belongs to the Special Issue At the Frontiers of Bipolar Disorder)
Background: Bipolar Disorders (BD) in youth are a heterogeneous condition with different phenomenology, patterns of comorbidity and outcomes. Our aim was to explore the effects of gender; age at onset (prepubertal- vs. adolescent-onset) of BD; and elements associated with attention deficit hyperactivity disorder (ADHD) and Substance Use Disorder (SUD) comorbidities, severe suicidal ideation or attempts, and poorer response to pharmacological treatments. Method: 117 youth (69 males and 57 females, age range 7 to 18 years, mean age 14.5 ± 2.6 years) consecutively referred for (hypo)manic episodes according to the Diagnostic and Statistical Manual of Mental Disorders, 54th ed (DSM 5) were included. Results: Gender differences were not evident for any of the selected features. Prepubertal-onset BD was associated with higher rates of ADHD and externalizing disorders. SUD was higher in adolescent-onset BD and was associated with externalizing comorbidities and lower response to treatments. None of the selected measures differentiated patients with or without suicidality. At a 6-month follow up, 51.3% of the patients were responders to treatments, without difference between those receiving and not receiving a psychotherapy. Clinical severity at baseline and comorbidity with Conduct Disorder (CD) and SUD were associated with poorer response. Logistic regression indicated that baseline severity and number of externalizing disorders were associated with a poorer outcome. Conclusions: Disentangling broader clinical conditions in more specific phenotypes can help timely and focused preventative and therapeutic interventions. View Full-Text
Keywords: bipolar disorders; children; adolescents: ADHD; substance use disorder; suicidality; anxiety disorders; externalizing disorders bipolar disorders; children; adolescents: ADHD; substance use disorder; suicidality; anxiety disorders; externalizing disorders
MDPI and ACS Style

Masi, G.; Berloffa, S.; Muratori, P.; Mucci, M.; Viglione, V.; Villafranca, A.; Inguaggiato, E.; Levantini, V.; Placini, F.; Pfanner, C.; D’Acunto, G.; Lenzi, F.; Liboni, F.; Milone, A. A Naturalistic Study of Youth Referred to a Tertiary Care Facility for Acute Hypomanic or Manic Episode. Brain Sci. 2020, 10, 689. https://doi.org/10.3390/brainsci10100689

AMA Style

Masi G, Berloffa S, Muratori P, Mucci M, Viglione V, Villafranca A, Inguaggiato E, Levantini V, Placini F, Pfanner C, D’Acunto G, Lenzi F, Liboni F, Milone A. A Naturalistic Study of Youth Referred to a Tertiary Care Facility for Acute Hypomanic or Manic Episode. Brain Sciences. 2020; 10(10):689. https://doi.org/10.3390/brainsci10100689

Chicago/Turabian Style

Masi, Gabriele, Stefano Berloffa, Pietro Muratori, Maria Mucci, Valentina Viglione, Arianna Villafranca, Emanuela Inguaggiato, Valentina Levantini, Francesca Placini, Chiara Pfanner, Giulia D’Acunto, Francesca Lenzi, Francesca Liboni, and Annarita Milone. 2020. "A Naturalistic Study of Youth Referred to a Tertiary Care Facility for Acute Hypomanic or Manic Episode" Brain Sciences 10, no. 10: 689. https://doi.org/10.3390/brainsci10100689

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop