Next Article in Journal
Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation
Previous Article in Journal
Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache
Previous Article in Special Issue
Cerebral Blood Flow in Low Intracranial Pressure Headaches—What Is Known?
Open AccessArticle

Differential Expression of CD31 and Von Willebrand Factor on Endothelial Cells in Different Regions of the Human Brain: Potential Implications for Cerebral Malaria Pathogenesis

1
Anatomy Unit, Department of Oncology, Microbiology and Immunology, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland
2
Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, 435101 Nnewi Campus, Nigeria
*
Authors to whom correspondence should be addressed.
Brain Sci. 2020, 10(1), 31; https://doi.org/10.3390/brainsci10010031
Received: 12 November 2019 / Revised: 31 December 2019 / Accepted: 3 January 2020 / Published: 6 January 2020
Cerebral microvascular endothelial cells (CMVECs) line the vascular system of the brain and are the chief cells in the formation and function of the blood brain barrier (BBB). These cells are heterogeneous along the cerebral vasculature and any dysfunctional state in these cells can result in a local loss of function of the BBB in any region of the brain. There is currently no report on the distribution and variation of the CMVECs in different brain regions in humans. This study investigated microcirculation in the adult human brain by the characterization of the expression pattern of brain endothelial cell markers in different brain regions. Five different brain regions consisting of the visual cortex, the hippocampus, the precentral gyrus, the postcentral gyrus, and the rhinal cortex obtained from three normal adult human brain specimens were studied and analyzed for the expression of the endothelial cell markers: cluster of differentiation 31 (CD31) and von-Willebrand-Factor (vWF) through immunohistochemistry. We observed differences in the expression pattern of CD31 and vWF between the gray matter and the white matter in the brain regions. Furthermore, there were also regional variations in the pattern of expression of the endothelial cell biomarkers. Thus, this suggests differences in the nature of vascularization in various regions of the human brain. These observations also suggest the existence of variation in structure and function of different brain regions, which could reflect in the pathophysiological outcomes in a diseased state. View Full-Text
Keywords: cerebral microvascular endothelial cells; variations; blood-brain barrier; cerebral microcirculation cerebral microvascular endothelial cells; variations; blood-brain barrier; cerebral microcirculation
Show Figures

Graphical abstract

MDPI and ACS Style

Mbagwu, S.I.; Filgueira, L. Differential Expression of CD31 and Von Willebrand Factor on Endothelial Cells in Different Regions of the Human Brain: Potential Implications for Cerebral Malaria Pathogenesis. Brain Sci. 2020, 10, 31.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop