Next Article in Journal
A Modeling Framework to Investigate the Influence of Fouling on the Dynamic Characteristics of PID-Controlled Heat Exchangers and Their Networks
Next Article in Special Issue
Chitosan as a Natural Copolymer with Unique Properties for the Development of Hydrogels
Previous Article in Journal
Laser Sintering of TiO2 Films for Flexible Dye-Sensitized Solar Cells
Previous Article in Special Issue
Mapping Nanoparticles in Hydrogels: A Comparison of Preparation Methods for Electron Microscopy

Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System

Instituteof Nanoscienceand Nanotechnology, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt
CNR NANOTEC-Istituto di Nanotecnologia, 73100 Lecce, Italy
Authors to whom correspondence should be addressed.
Appl. Sci. 2019, 9(5), 825;
Received: 11 February 2019 / Revised: 19 February 2019 / Accepted: 20 February 2019 / Published: 26 February 2019
(This article belongs to the Special Issue Nanocomposite Hydrogels for Biomedical Applications)
Hydrogels are widely used materials which have many medical applications. Their ability to absorb aqueous solutions and biological fluids gives them innovative characterizations resulting in increased compatibility with biological activity. In this sense, they are used extensively for encapsulation of several targets such as biomolecules, viruses, bacteria, and mammalian cells. Indeed, many methods have been published which are used in hydrogel formulation and biomedical encapsulations involving several cross-linkers. This system is still rich with the potential of undiscovered features. The physicochemical properties of polymers, distinguished by their interactions with biological systems into mucoadhesive, gastro-adhesive, and stimuli responsive polymers. Hydrogel systems may be assembled as tablets, patches, gels, ointments, and films. Their potential to be co-formulated as nanoparticles extends the limits of their assembly and application. In this review, mucoadhesive nanoparticles and their importance for biomedical applications are highlighted with a focus on mechanisms of overcoming mucosal resistance. View Full-Text
Keywords: hydrogel system; bioadhesion; mucoadhesion; mucus hydrogel system; bioadhesion; mucoadhesion; mucus
Show Figures

Figure 1

MDPI and ACS Style

Hanafy, N.A.N.; Leporatti, S.; El-Kemary, M.A. Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System. Appl. Sci. 2019, 9, 825.

AMA Style

Hanafy NAN, Leporatti S, El-Kemary MA. Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System. Applied Sciences. 2019; 9(5):825.

Chicago/Turabian Style

Hanafy, Nemany A.N., Stefano Leporatti, and Maged A. El-Kemary. 2019. "Mucoadhesive Hydrogel Nanoparticles as Smart Biomedical Drug Delivery System" Applied Sciences 9, no. 5: 825.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop