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Open AccessFeature PaperArticle

A Hybrid Nanoplatform of Graphene Oxide/Nanogold for Plasmonic Sensing and Cellular Applications at the Nanobiointerface

1
Laboratory of Hybrid NanoBioInterfaces (NHIL), Department of Chemical Sciences, University of Catania, viale Andrea Doria 6, 95125 Catania, Italy
2
Department of Chemical Sciences, University of Catania, viale Andrea Doria 6, 95125 Catania, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(4), 676; https://doi.org/10.3390/app9040676
Received: 31 December 2018 / Revised: 29 January 2019 / Accepted: 12 February 2019 / Published: 16 February 2019
(This article belongs to the Special Issue Nano-Biointerface for Biosensing)
In this study, nanocomposites of spherical gold nanoparticles (AuNPs) and graphene oxide (GO) nanosheets were fabricated by a simple one-step reduction method. The characterisation by UV-visible spectroscopy of the plasmonic sensing properties pointed out to a strong interaction between graphene and metal nanoparticles in the hybrid GO-AuNP, as confirmed by nuclear magnetic resonance. Moreover, atomic force microscopy analyses demonstrated that the gold nanoparticles were mostly confined to the basal planes of the GO sheets. The response of the nanoassemblies at the biointerface with human neuroblastoma SH-SY5Y cell line was investigated in terms of nanotoxicity as well as of total and mitochondrial reactive oxygen species production. Confocal microscopy imaging of cellular internalization highlighted the promising potentialities of GO-AuNP nanoplatforms for theranostic (i.e., sensing/imaging + therapy) applications. View Full-Text
Keywords: theranostics; Au nanoparticles; GO; neuroblastoma cells; NMR; AFM; nanotoxicity; ROS; confocal microscopy theranostics; Au nanoparticles; GO; neuroblastoma cells; NMR; AFM; nanotoxicity; ROS; confocal microscopy
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MDPI and ACS Style

Cucci, L.M.; Naletova, I.; Consiglio, G.; Satriano, C. A Hybrid Nanoplatform of Graphene Oxide/Nanogold for Plasmonic Sensing and Cellular Applications at the Nanobiointerface. Appl. Sci. 2019, 9, 676. https://doi.org/10.3390/app9040676

AMA Style

Cucci LM, Naletova I, Consiglio G, Satriano C. A Hybrid Nanoplatform of Graphene Oxide/Nanogold for Plasmonic Sensing and Cellular Applications at the Nanobiointerface. Applied Sciences. 2019; 9(4):676. https://doi.org/10.3390/app9040676

Chicago/Turabian Style

Cucci, Lorena M.; Naletova, Irina; Consiglio, Giuseppe; Satriano, Cristina. 2019. "A Hybrid Nanoplatform of Graphene Oxide/Nanogold for Plasmonic Sensing and Cellular Applications at the Nanobiointerface" Appl. Sci. 9, no. 4: 676. https://doi.org/10.3390/app9040676

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