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Appl. Sci. 2019, 9(4), 625;

Survey of Pharmacological Activity and Pharmacokinetics of Selected β-Adrenergic Blockers in Regard to Their Stereochemistry

Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University Bratislava, SK-832 32 Bratislava, Slovakia
Author to whom correspondence should be addressed.
Received: 18 January 2019 / Revised: 6 February 2019 / Accepted: 8 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Bioactive Substances: Properties, Applications and or Toxicities)
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The present survey concentrates on pharmacodynamics and pharmacokinetics of selected β-adrenergic blockers from the point of view of their stereochemistry. It could be shown that the activity in the arylaminoethanol and aryloxyaminopropanol group of β-blockers is higher in their (–)-enantiomers as compared with the (+)-enantiomers. The stereoisomers differ also in other types of bioactivity as well as in toxicity. The particular pharmacokinetic stages such as resorption, distribution, and metabolism are discussed in regard to their stereochemistry. View Full-Text
Keywords: beta-blockers; stereochemistry; pharmacodynamics; pharmacokinetics beta-blockers; stereochemistry; pharmacodynamics; pharmacokinetics

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Čižmáriková, R.; Habala, L.; Valentová, J.; Markuliak, M. Survey of Pharmacological Activity and Pharmacokinetics of Selected β-Adrenergic Blockers in Regard to Their Stereochemistry. Appl. Sci. 2019, 9, 625.

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