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Appl. Sci. 2019, 9(3), 557; https://doi.org/10.3390/app9030557

Peptide Mediated Antimicrobial Dental Adhesive System

1
Institute for Bioengineering Research, University of Kansas, 1530 W. 15th St., Lawrence, KS 66045, USA
2
Bioengineering Program, 1530 W. 15th St., University of Kansas, Lawrence, KS 66045, USA
3
Department of Molecular Biology and Genetics, Yildiz Technical University, 34210 Istanbul, Turkey
4
Department of Mechanical Engineering, 1530 W. 15th St., University of Kansas, Lawrence, KS 66045, USA
*
Author to whom correspondence should be addressed.
Received: 31 December 2018 / Revised: 30 January 2019 / Accepted: 5 February 2019 / Published: 8 February 2019
(This article belongs to the Special Issue Biofabrication: from Additive Bio-Manufacturing to Bioprinting)
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Abstract

The most common cause for dental composite failures is secondary caries due to invasive bacterial colonization of the adhesive/dentin (a/d) interface. Innate material weakness often lead to an insufficient seal between the adhesive and dentin. Consequently, bacterial by-products invade the porous a/d interface leading to material degradation and dental caries. Current approaches to achieve antibacterial properties in these materials continue to raise concerns regarding hypersensitivity and antibiotic resistance. Herein, we have developed a multi-faceted, bio-functionalized approach to overcome the vulnerability of such interfaces. An antimicrobial adhesive formulation was designed using a combination of antimicrobial peptide and a ε-polylysine resin system. Effector molecules boasting innate immunity are brought together with a biopolymer offering a two-fold biomimetic design approach. The selection of ε-polylysine was inspired due to its non-toxic nature and common use as food preservative. Biomolecular characterization and functional activity of our engineered dental adhesive formulation were assessed and the combinatorial formulation demonstrated significant antimicrobial activity against Streptococcus mutans. Our antimicrobial peptide-hydrophilic adhesive hybrid system design offers advanced, biofunctional properties at the critical a/d interface. View Full-Text
Keywords: antimicrobial peptide; polylysine; adhesive formulation; hybrid interface; dental composites antimicrobial peptide; polylysine; adhesive formulation; hybrid interface; dental composites
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Xie, S.-X.; Boone, K.; VanOosten, S.K.; Yuca, E.; Song, L.; Ge, X.; Ye, Q.; Spencer, P.; Tamerler, C. Peptide Mediated Antimicrobial Dental Adhesive System. Appl. Sci. 2019, 9, 557.

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