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Synthesis and Surface Modification of Nanostructured F-Doped ZnO: Toward a Transducer for Label-Free Optical Biosensing

1
National Research Council, Institute for Microelectronics and Microsystems, Unit of Naples, 80131 Naples, Italy
2
Department of Chemical Sciences, Federico II University of Naples, 80138 Naples, Italy
3
Department of Chemical, Materials and Production Engineering, Federico II University of Naples, 80138 Naples, Italy
4
Department of Physics, Federico II University of Naples, 80138 Naples, Italy
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(16), 3380; https://doi.org/10.3390/app9163380
Received: 9 July 2019 / Revised: 8 August 2019 / Accepted: 12 August 2019 / Published: 16 August 2019
(This article belongs to the Section Chemistry)
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Abstract

In this work, the surface of nanostructured fluorine-doped ZnO (nZnO·F) is functionalized with protein A (PrA), and used as a model biomolecule. The chemical procedure is characterized by several analytical techniques such as Fourier Transform Infrared Spectroscopy, water contact angle analysis, and fluorescence microscopy. The surface modification of nZnO·F by binding increasing concentrations of PrA is also investigated by two label-free optical techniques, i.e., the spectroscopic reflectometry and the steady-state photoluminescence. The results are compared with those obtained using undoped nZnO substrates in order to highlight the better performances of nZnO·F due to the fluorine doping. The results of this study pave the way for the design and realization of a ZnO-based nanostructured platform for label-free optical sensing. View Full-Text
Keywords: nanostructured zinc oxide; hydrothermal synthesis; bioconjugation; photoluminescence nanostructured zinc oxide; hydrothermal synthesis; bioconjugation; photoluminescence
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Chianese, G.; Terracciano, M.; Moretta, R.; Cappiello, P.; Vitiello, G.; Aronne, A.; Schiattarella, C.; De Stefano, L.; Rea, I. Synthesis and Surface Modification of Nanostructured F-Doped ZnO: Toward a Transducer for Label-Free Optical Biosensing. Appl. Sci. 2019, 9, 3380.

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