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Open AccessArticle

Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant

1
Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan
2
Division of Dysphagia Rehabilitation, Niigata University Graduate School of Medical and Dental Sciences, Niigata University, 2-5274, Gakkocho-dori, Chuo-ku, Niigata 951-8514, Japan
3
Division of Preventive Dentistry, Tohoku University Graduate School of Dentistry, Tohoku University, 4–1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan
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Institute for Materials Chemistry and Engineering, Kyushu University, CE41 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
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Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Tohoku University, 4–1 Seiryo-machi Aoba-ku, Sendai 980-8575, Japan
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Division of Multi-Functional Materials, Institute for Materials Research, Tohoku University, 2–2–1 Katahira Aoba-ku, Sendai 980-8577, Japan
*
Author to whom correspondence should be addressed.
Appl. Sci. 2019, 9(1), 172; https://doi.org/10.3390/app9010172
Received: 7 December 2018 / Revised: 25 December 2018 / Accepted: 27 December 2018 / Published: 4 January 2019
(This article belongs to the Special Issue Permanent and Long-Term Biodegradable Biomaterials)
Calcium Titanate (CaTiO3) has been introduced as an attractive biomaterial for the enhancement of calcium phosphate deposition in vivo and in vitro. We hypothesized that CaTiO3 directly coated on titanium (Ti) by metal-organic chemical vapor deposition (MOCVD) could be a suitable candidate for biocompatible coatings for medical devices, particularly dental implants. To prove this hypothesis, surface characterization, cell culture, and animal study were completed in this study. The result of this study showed that CTO 800, a CaTiO3 film prepared by heating at 800 °C, had a high hydrophilic surface. Mouse bone marrow stromal ST-2 cells cultured on substrates and CTO 800 exhibited cell differentiation, represented by alkaline phosphatase activity, compared with cells cultured on non-coated Ti and CTO 700 (a CaTiO3 film prepared by heating at 700 °C). The push-in test value of CTO 800, a parameter that indicates the degree of osseointegration, was significantly higher than that of Ti. Calcium titanate coated on Ti by MOCVD has the potential to accelerate the process of osseointegration; thus, our results support the use of CaTiO3 coating for biocompatible biomaterial for medical applications, particularly dental implants. View Full-Text
Keywords: calcium titanate; metal-organic chemical vapor deposition; dental implant calcium titanate; metal-organic chemical vapor deposition; dental implant
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Shiraishi, N.; Ishiko-Uzuka, R.; Takahashi, K.; Ogawa, T.; Anada, T.; Suzuki, O.; Goto, T.; Sasaki, K. Effect of Functionally-Graded Calcium Titanate Film, Prepared by Metal-Organic Chemical Vapor Deposition, on Titanium Implant. Appl. Sci. 2019, 9, 172.

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