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Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Medizinische Klinik 2, Caritas-Krankenhaus Bad Mergentheim, Uhlandstraße 7, 97980 Bad Mergentheim, Germany
Department of Gastroenterology and Hepatology, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
Ultrasound Unit, Clinical Sciences and Infectious Diseases Department, Fondazione IRCCS Policlinico San Matteo, Medical School University of Pavia, 27100 Pavia, Italy
Pediatrics Department, “Victor Babeș” University of Medicine and Pharmacy Timișoara, 300041 Timișoara, Romania
Klinik für Radiologie, Abteilung Kinderradiologie, Universitätsklinikum Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, 06120 Halle, Germany
Klinik und Poliklinik für Kinder-und Jugendmedizin, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, 01307 Dresden, Germany
Klinik für Diagnostische und Interventionelle Radiologie, University of Aachen, 52062 Aachen, Germany
Department of Gastroenterology, Hepatology, Nephrology and Endocrinology, Klinikum Klagenfurt am Wörthersee, 9020 Klagenfurt am Wörthersee, Austria
Department of ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200433, China
Author to whom correspondence should be addressed.
Appl. Sci. 2018, 8(6), 944;
Received: 2 April 2018 / Revised: 21 May 2018 / Accepted: 28 May 2018 / Published: 7 June 2018
(This article belongs to the Special Issue Ultrasound Elastography)
PDF [1105 KB, uploaded 7 June 2018]


Studies performed using transient elastography (TE), point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) have shown that these techniques are all feasible and accurate in children for the evaluation of liver fibrosis due to several etiologies. However, for some specific pediatric pathologies, such as biliary atresia, the evidence is still limited. As shown in adults, inflammation is a confounding factor when assessing fibrosis severity and care should be taken when interpreting the results. Due to the scarce comparative data between serological tests and elastography techniques in children, a definite conclusion regarding which is the best cannot be drawn. Neither non-invasive elastographic techniques nor laboratory scores allow determination of the presence and the degree of inflammation, necrosis, iron or copper deposits. View Full-Text
Keywords: ultrasound elastography; pediatric; liver fibrosis; stiffness; shear wave elastography (SWE) ultrasound elastography; pediatric; liver fibrosis; stiffness; shear wave elastography (SWE)

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Dietrich, C.F.; Sirli, R.; Ferraioli, G.; Popescu, A.; Sporea, I.; Pienar, C.; Kunze, C.; Taut, H.; Schrading, S.; Bota, S.; Schreiber-Dietrich, D.; Yi, D. Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients. Appl. Sci. 2018, 8, 944.

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