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Article

Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus

by
Song Yi Lee
1,†,
Suyeong Nam
1,†,
Yohan Choi
2,
Minju Kim
2,
Ja Seong Koo
1,
Byung-Jo Chae
2,
Wie-Soo Kang
3 and
Hyun-Jong Cho
1,*
1
College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Korea
2
Department of Animal Resources Science, College of Animal Life Sciences, Kangwon National University, Chuncheon, Gangwon 24341, Korea
3
School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 24341, Korea
*
Author to whom correspondence should be addressed.
†
These authors equally contributed to this work.
Appl. Sci. 2017, 7(9), 902; https://doi.org/10.3390/app7090902
Submission received: 20 July 2017 / Revised: 30 August 2017 / Accepted: 1 September 2017 / Published: 4 September 2017
(This article belongs to the Section Nanotechnology and Applied Nanosciences)
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Abstract

Zinc sulfate monohydrate (ZnSO4)-loaded nanocomposites (NCs) were fabricated by using a hot-melt extruder (HME) system. Soluplus (SP) was adopted as an amphiphilic polymer matrix for HME processing. The micro-size of ZnSO4 dispersion was reduced to nano-size by HME processing with the use of SP. ZnSO4 could be homogeneously dispersed in SP through HME processing. ZnSO4/SP NCs with a 75 nm mean diameter, a 0.1 polydispersity index, and a −1 mV zeta potential value were prepared. The physicochemical properties of ZnSO4/SP NCs and the existence of SP in ZnSO4/SP NCs were further investigated by solid-state studies. Nano-size range of ZnSO4/SP NC dispersion was maintained in the simulated gastrointestinal environments (pH 1.2 and 6.8 media). No severe toxicity in intestinal epithelium after oral administration of ZnSO4/SP NCs (at 100 mg/kg dose of ZnSO4, single dosing) was observed in rats. These results imply that developed ZnSO4/SP NC can be used as a promising nano-sized zinc supplement formulation. In addition, developed HME technology can be widely applied to fabricate nanoformulations of inorganic materials.
Keywords: hot-melt extrusion; nanocomposite; Soluplus; zinc sulfate monohydrate hot-melt extrusion; nanocomposite; Soluplus; zinc sulfate monohydrate
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MDPI and ACS Style

Lee, S.Y.; Nam, S.; Choi, Y.; Kim, M.; Koo, J.S.; Chae, B.-J.; Kang, W.-S.; Cho, H.-J. Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus. Appl. Sci. 2017, 7, 902. https://doi.org/10.3390/app7090902

AMA Style

Lee SY, Nam S, Choi Y, Kim M, Koo JS, Chae B-J, Kang W-S, Cho H-J. Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus. Applied Sciences. 2017; 7(9):902. https://doi.org/10.3390/app7090902

Chicago/Turabian Style

Lee, Song Yi, Suyeong Nam, Yohan Choi, Minju Kim, Ja Seong Koo, Byung-Jo Chae, Wie-Soo Kang, and Hyun-Jong Cho. 2017. "Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus" Applied Sciences 7, no. 9: 902. https://doi.org/10.3390/app7090902

APA Style

Lee, S. Y., Nam, S., Choi, Y., Kim, M., Koo, J. S., Chae, B.-J., Kang, W.-S., & Cho, H.-J. (2017). Fabrication and Characterizations of Hot-Melt Extruded Nanocomposites Based on Zinc Sulfate Monohydrate and Soluplus. Applied Sciences, 7(9), 902. https://doi.org/10.3390/app7090902

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