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Open AccessArticle

A Liquid-Solid Coupling Hemodynamic Model with Microcirculation Load

by Bai Li * and Xiaoyang Li
Biomechanical Research Laboratory, Center of Engineering Mechanics, Beijing University of Technology, No.100 Pingleyuan, Chaoyang District, Beijing 100124, China
Author to whom correspondence should be addressed.
Academic Editor: Yang Kuang
Appl. Sci. 2016, 6(1), 28;
Received: 17 November 2015 / Revised: 23 December 2015 / Accepted: 13 January 2016 / Published: 20 January 2016
(This article belongs to the Special Issue Dynamical Models of Biology and Medicine)
From the aspect of human circulation system structure, a complete hemodynamic model requires consideration of the influence of microcirculation load effect. This paper selected the seepage in porous media as the simulant of microcirculation load. On the basis of a bi-directional liquid-solid coupling tube model, we built a liquid-solid-porous media seepage coupling model. The simulation parameters accorded with the physiological reality. Inlet condition was set as transient single-pulse velocity, and outlet as free outlet. The pressure in the tube was kept at the state of dynamic stability in the range of 80–120 mmHg. The model was able to simulate the entire propagating process of pulse wave. The pulse wave velocity simulated was 6.25 m/s, which accorded with the physiological reality. The complex pressure wave shape produced by reflections of pressure wave was also observed. After the model changed the cardiac cycle length, the pressure change according with actual human physiology was simulated successfully. The model in this paper is well-developed and reliable. It demonstrates the importance of microcirculation load in hemodynamic model. Moreover the properties of the model provide a possibility for the simulation of dynamic adjustment process of human circulation system, which indicates a promising prospect in clinical application. View Full-Text
Keywords: hemodynamic model; microcirculation load; liquid-solid-porous media seepage coupling hemodynamic model; microcirculation load; liquid-solid-porous media seepage coupling
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Li, B.; Li, X. A Liquid-Solid Coupling Hemodynamic Model with Microcirculation Load. Appl. Sci. 2016, 6, 28.

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