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The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging

1
Department of Neurology, Pudong People’s Hospital, Shanghai 201299, China
2
Department of Radiology, Pudong People’s Hospital, Shanghai 201299, China
*
Author to whom correspondence should be addressed.
Academic Editor: Philippe Lambin
Appl. Sci. 2015, 5(4), 1076-1085; https://doi.org/10.3390/app5041076
Received: 26 August 2015 / Revised: 25 October 2015 / Accepted: 27 October 2015 / Published: 10 November 2015
(This article belongs to the Section Nanotechnology and Applied Nanosciences)
The most notable obstacle of brain cancer diagnosis is the inability of delivering imaging agents across the blood-brain barrier (BBB). Recently, quantum dots (QDs) has been demonstrated as an ideal image agent for brain imaging due to their ultra-small size for crossing BBB. The plolyamidoamine dendrimers modified CdTe/CdS core/shell near-infrared (NIR) region QDs was successfully synthesized in aqueous solution, and then was characterized by UV-vis absorption, photoluminescence (PL) spectroscopy, dynamic light scattering (DLS), X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM), etc. Our results reveal that the dendrimers modified CdTe/CdS QDs exhibits good water-dispersity and stable NIR fluorescence in various biological environments. In addition, this NIR QDs demonstrates a good biocompatibility and sensitive photoluminescence responses in brain tumor cell imaging. In a word, this type of dendrimers modified NIR CdTe/CdS QDs has huge potential applications in brain imaging. View Full-Text
Keywords: noninvasive cancer diagnosis; brain imaging; nanotechnology; near infrared; quantum dots noninvasive cancer diagnosis; brain imaging; nanotechnology; near infrared; quantum dots
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MDPI and ACS Style

Bai, Q.; Zhao, Z.; Sui, H.; Chen, J.; Xie, X.; Wen, F. The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging. Appl. Sci. 2015, 5, 1076-1085. https://doi.org/10.3390/app5041076

AMA Style

Bai Q, Zhao Z, Sui H, Chen J, Xie X, Wen F. The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging. Applied Sciences. 2015; 5(4):1076-1085. https://doi.org/10.3390/app5041076

Chicago/Turabian Style

Bai, Qingke, Zhenguo Zhao, Haijing Sui, Juan Chen, Xiuhai Xie, and Feng Wen. 2015. "The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging" Applied Sciences 5, no. 4: 1076-1085. https://doi.org/10.3390/app5041076

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