A Novel Method Combining Radial Projection with Simultaneous Multislice Imaging for Measuring Cerebrovascular Pulse Wave Velocity

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

Dear authors,

This study introduces a novel method that combines radial projection with simultaneous multi-slice imaging (SMS) to measure cerebrovascular pulse wave velocity (PWV). The method aims to reduce signal interference between blood vessels due to vertical projection within the same hemisphere.

This article is well-articulated and beautifully written. While there are a few areas where further clarification would significantly enhance the paper's impact. I recommend minor revisions to address these points.

Specific comments:

1. It would be informative to understand whether the study took into account the influence of varying vessel diameters and locations on the MAE, particularly with respect to signal interference involving the ICA and CCA?

2. Could the authors detail on how the "radial projection" technique mitigates or prevents signal interference between blood vessels, and what distinct advantages this method offers compared to the "vertical projection" in preserving signal integrity?

3. Did the study compare PWV measurement results between the simulation, undersampled, and interpolated datasets, and what insights do these comparisons offer for the study's conclusions? 

4. Lastly, I am personally interested in whether the study could report on the assessment of how different noise levels affect the accuracy of PWV measurements within the simulation, undersampled, and interpolated datasets.

 

Reviewer.

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

Many thanks for giving to me the possibility of reviewing this valuable manuscript that aims to Improve Vascular Elasticity Measurement with Radial Projection in MRI. Since increasing temporal resolution and accounting for noise variability are crucial for accurate PWV measurement in cerebrovascular imaging, Authors looked for more reliable vascular elasticity assessments to enhance diagnostic precision for cerebrovascular diseases and this study compared vertical projection and radial projection methods for pulse wave velocity (PWV) measurement, using simulated and real MRI datasets. 

 

Methods were well exposed, and results clearly reported. 

 

Findings seem coherent with premises.

 

Images and tables really help readers understanding the subject.

 

The English language in good and no issues were detected.

 

I suggest adding a conclusion paragraph that will improve readability.

Author Response

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Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

The authors have explored a novel method for measuring cerebrovascular PWV using a radial projection method that can reduce signal interference between the blood vessels and aimed to verify the theoretical and practical effects of this method. In general, the manuscript is well written and the flow is good and much comprehensible for an average reader. 

1. How do you justify measuring the arterial stiffness in only 10 patients?

2. How can the results be generalizable from such a small sample sized study?

3. On the same line, how can you justify using a parametric statistical tests for comparison of PWV values between the samples?

4. Also, as statistical tests have been carried out so many times, it increases the risk of type 1 error. So, atleast using Bonferroni correction method would take care of adjusting type 1 error. This ought to be considered given such a small sample size.

 

Author Response

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Author Response File: Author Response.pdf

Round 2

Reviewer 3 Report

Comments and Suggestions for Authors

Thanks for the revision