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Article

MultiScaleFusion-Net and ResRNN-Net: Proposed Deep Learning Architectures for Accurate and Interpretable Pregnancy Risk Prediction

1
Department of Computer Science, Aberystwyth University, Penglais Campus, Aberystwyth SY23 3FL, UK
2
Department of Physics, Aberystwyth University, Penglais Campus, Aberystwyth SY23 3FL, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Appl. Sci. 2025, 15(11), 6152; https://doi.org/10.3390/app15116152
Submission received: 16 April 2025 / Revised: 14 May 2025 / Accepted: 16 May 2025 / Published: 30 May 2025
(This article belongs to the Special Issue Application of Artificial Intelligence in Biomedical Informatics)

Abstract

Women exhibit marked physiological transformations in pregnancy, mandating regular and holistic assessment. Maternal and fetal vitality is governed by a spectrum of clinical, demographic, and lifestyle factors throughout this critical period. The existing maternal health monitoring techniques lack precision in assessing pregnancy-related risks, often leading to late interventions and adverse outcomes. Accurate and timely risk prediction is crucial to avoid miscarriages. This research proposes a deep learning framework for personalized pregnancy risk prediction using the NFHS-5 dataset, and class imbalance is addressed through a hybrid NearMiss-SMOTE approach. Fifty-one primary features are selected via the LASSO to refine the dataset and enhance model interpretability and efficiency. The framework integrates a multimodal model (NFHS-5, fetal plane images, and EHG time series) along with two core architectures. ResRNN-Net further combines Bi-LSTM, CNNs, and attention mechanisms to capture sequential dependencies. MultiScaleFusion-Net leverages GRU and multiscale convolutions for effective feature extraction. Additionally, TabNet and MLP models are explored to compare interpretability and computational efficiency. SHAP and Grad-CAM are used to ensure transparency and explainability, offering both feature importance and visual explanations of predictions. The proposed models are trained using 5-fold stratified cross-validation and evaluated with metrics including accuracy, precision, recall, F1-score, and ROC–AUC. The results demonstrate that MultiScaleFusion-Net balances accuracy and computational efficiency, making it suitable for real-time clinical deployment, while ResRNN-Net achieves higher precision at a slight computational cost. Performance comparisons with baseline machine learning models confirm the superiority of deep learning approaches, achieving over 80% accuracy in pregnancy complication prediction.
Keywords: maternal health prediction; deep learning in healthcare; pregnancy complication detection; explainable AI (XAI) in medicine; SHAP and GradCAM interpretability; imbalanced data handling; clinical decision support systems maternal health prediction; deep learning in healthcare; pregnancy complication detection; explainable AI (XAI) in medicine; SHAP and GradCAM interpretability; imbalanced data handling; clinical decision support systems

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MDPI and ACS Style

Asad, A.; Sarwar, M.; Aslam, M.; Akpokodje, E.; Jilani, S.F. MultiScaleFusion-Net and ResRNN-Net: Proposed Deep Learning Architectures for Accurate and Interpretable Pregnancy Risk Prediction. Appl. Sci. 2025, 15, 6152. https://doi.org/10.3390/app15116152

AMA Style

Asad A, Sarwar M, Aslam M, Akpokodje E, Jilani SF. MultiScaleFusion-Net and ResRNN-Net: Proposed Deep Learning Architectures for Accurate and Interpretable Pregnancy Risk Prediction. Applied Sciences. 2025; 15(11):6152. https://doi.org/10.3390/app15116152

Chicago/Turabian Style

Asad, Amna, Madiha Sarwar, Muhammad Aslam, Edore Akpokodje, and Syeda Fizzah Jilani. 2025. "MultiScaleFusion-Net and ResRNN-Net: Proposed Deep Learning Architectures for Accurate and Interpretable Pregnancy Risk Prediction" Applied Sciences 15, no. 11: 6152. https://doi.org/10.3390/app15116152

APA Style

Asad, A., Sarwar, M., Aslam, M., Akpokodje, E., & Jilani, S. F. (2025). MultiScaleFusion-Net and ResRNN-Net: Proposed Deep Learning Architectures for Accurate and Interpretable Pregnancy Risk Prediction. Applied Sciences, 15(11), 6152. https://doi.org/10.3390/app15116152

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