Flavone Hybrids and Derivatives as Bioactive Agents

Hazai, László; Zsoldos, Bernadett; Halmai, Mónika; Keglevich, Péter

doi:10.3390/app14031039

Open AccessReview

Flavone Hybrids and Derivatives as Bioactive Agents

by

László Hazai

,

Bernadett Zsoldos

,

Mónika Halmai

and

Péter Keglevich

^*

Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3, H-1111 Budapest, Hungary

^*

Author to whom correspondence should be addressed.

Appl. Sci. 2024, 14(3), 1039; https://doi.org/10.3390/app14031039

Submission received: 24 November 2023 / Revised: 20 January 2024 / Accepted: 23 January 2024 / Published: 25 January 2024

(This article belongs to the Special Issue Pharmacological Activity, Biochemical Properties, and Clinical Applications of Synthetic and Natural Compounds)

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Abstract

Hybrid molecules can be defined as chemical entities with two or more structural domains, namely pharmacophores, having a specific biological effect. In many cases, when at least one of the components is biologically inactive, it is rather correct to call them “derivatives”, despite the fact that in the literature they are often mentioned also as hybrids. We have summarized such types of molecules, in which one of the components is mostly a real pharmacophore, i.e., flavone, which is one of the best-known natural bioactive substances. Structures, synthetic methods, medicinal indications, and more important activity data are presented.

Keywords: flavones; hybrid molecules; derivatives; synthetic routes; bioactivity

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MDPI and ACS Style

Hazai, L.; Zsoldos, B.; Halmai, M.; Keglevich, P. Flavone Hybrids and Derivatives as Bioactive Agents. Appl. Sci. 2024, 14, 1039. https://doi.org/10.3390/app14031039

AMA Style

Hazai L, Zsoldos B, Halmai M, Keglevich P. Flavone Hybrids and Derivatives as Bioactive Agents. Applied Sciences. 2024; 14(3):1039. https://doi.org/10.3390/app14031039

Chicago/Turabian Style

Hazai, László, Bernadett Zsoldos, Mónika Halmai, and Péter Keglevich. 2024. "Flavone Hybrids and Derivatives as Bioactive Agents" Applied Sciences 14, no. 3: 1039. https://doi.org/10.3390/app14031039

APA Style

Hazai, L., Zsoldos, B., Halmai, M., & Keglevich, P. (2024). Flavone Hybrids and Derivatives as Bioactive Agents. Applied Sciences, 14(3), 1039. https://doi.org/10.3390/app14031039

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Flavone Hybrids and Derivatives as Bioactive Agents

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