Non-Plaque Induced Diffuse Gingival Overgrowth: An Overview

Round 1

Reviewer 1 Report

This review, by De Falco, D., et al., tried to give an updated overview in the field of non-plaque induced diffuse gingival overgrowth, and attempted to emphasize in suggesting for patients’ diagnostic practices and facilitating clinical treatments/management.  

This reviewer thinks the structure of the manuscript is well built, the summary is up-to-date, the discussion in each section is logically presented and with relevant practical suggestions.  The table is helpful and clearly presented.  These are all important elements for a good review article.  However, there are numerous grammatical and sentence structural errors, that it is hard to read.

Here are a few examples (and there are many more) of the errors that the authors should fix:

• P1, line 19, should be “chromosomal”
• P1, line 20, should be “phenotypic”
• P1, line 21, “throught” – do you mean “throughout”, or “through”, or “thought”
• P1, line 22, should be “facilitated”
• P1, line 39, “detemining” – do you mean “denoting”? Or “determining”?
• P2, line 72, should be either “1,000,000” or “one million”, but not both
• P3, line 82, should be “cobble stones”
• P4, line 159, should be “throughout”
• P14, line 422, should be “Secondly”
• P14, line 427, should be “expolore the patients’”
• P14, line 430, “……. patients’ physiological functions give pictures regarding the types of diet, ……”
• Line 431, “……for the clinician is to be informed……”
• Line 433, “……DIGOs that appear after ……”
• Line 437-438, “……in order to obtain information reguarding ……
• Line 443, “…… develop later in the years life.”
• Line 445, “allert”
• Line 582, “ese” – do you mean “these”?
• Line 583, “oivotal” – do you mean “pivotal”?
• Line 584, “……approach towards an individualized diagnosis ……”
• Line 589, “…… a diagnosis is of crucial”

Author Response

Dear Reviewer,

Grammatical errors have been corrected.

Reviewer 2 Report

Author Response

Dear Reviewer,

This narrative review of the literature aims to list in detail all non-plaque-induced gingival volume increases. Our aim is to provide the reader with detailed guidance on the various clinical manifestations and a guide to diagnosis.
We also focused our attention on isolated genetic forms but above all syndromic, reorganizing what was present in the literature.

Reviewer 3 Report

1. Lines 74, 75: Need to present in more detail after how many months of drug assumption We can detect the sign of DIGO.
2. Line 91.92: It’s better if you can make a comparison table describing different characteristics according to the type of drug involved.
3. About the leukemias and lymphomas, It’s better if you can make a comparison table describing different and similar characteristics between type of leukemias and lymphomas (acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, lymphonas).
4. About the histopathological examination: need to show the recommendation or the indication regarding the biopsy,Which cases do you need to have the biopsy. Furthemore, you can make a a comparison table describing different and similar characteristics between type of non plaque induced diffuse gingival overgrowth

Author Response

1)We have specified after how many months of drug assumption We can detect the sign of DIGO.

2)The comparison table has been made.

3)The comparison table has been made.

4)We have created a table that contains both information

Reviewer 4 Report

Dear Authors,

I appreciate the efforts you made for the article entitled NON PLAQUE INDUCED DIFFUSE GINGIVAL OVERGROWTH: AN OVERWIEW.
In my opinion, there are a number of shortcomings of the article, as follows:
- the article does not have a Methodology chapter. Even narrative review articles (as you specified in the introductory part that this article is) must be subject to certain rigor in implementation. Therefore, I consider it essential to add a Chapter of Methodology, in which to specify the scientific databases consulted, the criteria considered and the time period analyzed.
-English expression is incorrect in many places, starting with the title (you probably intended to write "an overview", not "an overwiew"). Therefore, a correction of the English language is required for the entire article
- the names of some bacterial species are not spelled correctly: for example,  consider P. "gingivalis" instead of "gengivalis" and "actinomycetemcomitans" instead of "actinomycetecomitans"
-line 72 - numeric expression is confusing
- in the chapter on clinical examination - consider "gingiva" instead of "gengiva".
-I recommend you to consult some more recent bibliographical references that exist in the scientific literature regarding the subject approached in the article.

Author Response

1)Methodology chapter was added

2)Grammatical errors have been corrected

3)The name of bacterial species have been corrected

4)Numeric expression has been corrected

5)The error has been corrected

6)We have added more recent references

Round 2

Reviewer 2 Report

Dear Authors

Wyniki tłumaczenia

Author Response

Dear Reviewer

Thank you for the positive evaluation of our work.

Reviewer 3 Report

The author have corrected and added some content. This paper is valuable and informative, which can be accepted after correcting somes English minor errors.

Best reagard!

Author Response

Dear Reviewer

Thanks for your suggestions. The article has been corrected.

Reviewer 4 Report

Dear Authors, 

Thank you for taking into account my recommendations on the article entitled NON-PLAQUE INDUCED DIFFUSE GINGIVAL OVERGROWTH: AN OVERVIEW.

Here are some recommendations to further improve the quality of this paper:

-line 83: the particle "of" should be removed from the expression "of gingival enlargement";

-Table 1: it is not referred to in the text;

-Table 1: consider "contraceptives" instead of "contracceptives";

-line 149: consider "turn-over" instead of "tourn-over";

-line 159: consider "than" instead of "thank";

-line 172: what is "gingival-periodontitis"? The expression is confusing;

-line 174: consider "present" instead of "presents";

-line 176: consider "this" instead of "these";

-line 191: consider "Streptococcus mutans" or "mutans streptococci" instead of "Streptococci mutans";

-line 301: please rephrase "a higher in the amount of";

-line 318: replace "Table 1" with "Table 2";

-line 402: replace "is " with "are";

-line 427: "of very important" - please remove "of";

-Table 3:  it is not referred to in the text;

-line 469: please rephrase;

-line 491: replace "NPIGOs has" with "NPIGOs have";

-line 510: "extend gingiva extended" - please rephrase;

-line 554: "we will show" - please remove "we";

-line 593 - please rephrase;

-line 596 - please rephrase;

-Table 4:  it is not referred to in the text; 

-Table 4: for "DIGO":  "Regression with drug suspension of the drug" - please rephrase;

-the "Conclusions" chapter should not contain citations, but the opinion of the authors on the researched aspects.

Author Response

Dear Reviewer

Thanks for your suggestions. The article has been modified following your instructions.