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Applied Sciences
Volume 12
Issue 21
10.3390/app122110924
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Article
Peer-Review Record

The Presence of Impacted Teeth (Except for Wisdom Teeth) in Orthodontic Patients in Israel

Appl. Sci. 2022, 12(21), 10924; https://doi.org/10.3390/app122110924
by Nir Shpack 1, Chaya Afarsemon Kisoss 2 and Amir Laviv 3,*
Reviewer 1:
Kuo-Chou Chiu
Reviewer 2:
Alexandru Vlasa
Appl. Sci. 2022, 12(21), 10924; https://doi.org/10.3390/app122110924
Submission received: 12 October 2022 / Revised: 21 October 2022 / Accepted: 22 October 2022 / Published: 28 October 2022
(This article belongs to the Special Issue Present and Future of Orthodontics)

Round 1

Reviewer 1 Report

The authors used a cohort study to analyze Israel's prevalence of impacted teeth (excluding wisdom teeth). The results were valuable for developmental research. I wonder why the authors used 45 cohort experiments and 45 control patients for analysis. Why did the authors not use the total cases of 1654 patients searching for orthodontic treatment and the 197 patients with impacted teeth? Are there differences between the experimental design?

Since the authors wanted to relate genetics with impacted teeth, are there any environmental effects on the affected teeth, not just genetic problems, from this research design? I think there should be less confirmation of the genetic issues related to the impacted teeth because the authors do not analyze the patient's genetic maps. There still have some reasons associated with the impaction, and the authors may discuss more in the discussion section.

Author Response

The main cohort included 1654 patients, with 197 patients treated for impacted teeth. The cohort is large, however for statistical significance and power, we do not need the whole cohort, but just a random sample from it. That is the reason we picked only 45 cases from the impacted teeth, and 45 cases for control (paired for sex and age - for similarity to the test group).

the genetic relation to impacted teeth is well known (as also found in our research), however other options are possible. this was discussed in the introduction section (lines 37-50 - the possible causes for impacted teeth). In our study we checked only the genetic other teeth anomalies of first degree relatives. in the discussion, we added a sentence regarding the other causes for teeth impaction (line 181-182). 

 

Reviewer 2 Report

Dear Authors,

Congratulations on the work you have done and presented in this manuscript. I believe that your work can be published after some minor changes and text editing. Please see the attachment.

Comments for author File: Comments.pdf

Author Response

Thank you very much for the detailed remarks.

All remarks have been fixed in the manuscript. 

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