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Applied Sciences
Volume 12
Issue 15
10.3390/app12157734
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Case Report

Radiotherapy and Immunotherapy, Combined Treatment for Unresectable Mucosal Melanoma with Vaginal Origin

by
Laura Rebegea
1,2,3,
Dorel Firescu
4,
Gabriela Stoleriu
2,5,*,
Manuela Arbune
2,
Rodica Anghel
6,
Mihaela Dumitru
1,
Raul Mihailov
2,
Anca Iulia Neagu
6 and
Xenia Bacinschi
7
1
Department of Radiotherapy, ‘St. Apostol Andrei’ Emergency Clinical Hospital, 800578 Galati, Romania
2
Clinical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania
3
Research Center in the Field of Medical and Pharmaceutical Sciences, ReFORM-UDJ, ‘Dunarea de Jos’ University, 800010 Galati, Romania
4
Surgical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania
5
‘St. Spiridon’ Hospital, 700111 Iași, Romania
6
Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University, 800010 Galati, Romania
7
8th Department, Faculty of Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Appl. Sci. 2022, 12(15), 7734; https://doi.org/10.3390/app12157734
Submission received: 27 May 2022 / Revised: 17 July 2022 / Accepted: 18 July 2022 / Published: 1 August 2022
(This article belongs to the Special Issue New Challenges in Skin Cancer)
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Abstract

Gynecologic melanomas are uncommon and malignant mucosal melanomas with vaginal origin are extremely rare, treatment strategies are limited and extrapolated from those of cutaneous melanoma. A better understanding of the vulvovaginal melanoma’s biology and its risk factors is needed. Therapeutic strategies include surgery, systemic therapy and radiotherapy. For vulvovaginal melanoma, surgery is selected as the primary treatment. Immunotherapy and target treatment have recently enhanced the systemic therapy for cutaneous melanoma (CM). Immunotherapy and new target agents demonstrated a better survival of melanoma and might be considered as treatment of vulvovaginal melanoma. Radiotherapy is included in the therapeutic arsenal for mucosal melanoma and may be performed on selected patients who may receive concurrent checkpoints and inhibition neoadjuvant radiotherapy with the purpose of reducing morbidity and mortality.
Keywords: gynecologic melanomas; mucosal melanomas; vulvovaginal melanomas; immunotherapy; radiotherapy gynecologic melanomas; mucosal melanomas; vulvovaginal melanomas; immunotherapy; radiotherapy

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MDPI and ACS Style

Rebegea, L.; Firescu, D.; Stoleriu, G.; Arbune, M.; Anghel, R.; Dumitru, M.; Mihailov, R.; Neagu, A.I.; Bacinschi, X. Radiotherapy and Immunotherapy, Combined Treatment for Unresectable Mucosal Melanoma with Vaginal Origin. Appl. Sci. 2022, 12, 7734. https://doi.org/10.3390/app12157734

AMA Style

Rebegea L, Firescu D, Stoleriu G, Arbune M, Anghel R, Dumitru M, Mihailov R, Neagu AI, Bacinschi X. Radiotherapy and Immunotherapy, Combined Treatment for Unresectable Mucosal Melanoma with Vaginal Origin. Applied Sciences. 2022; 12(15):7734. https://doi.org/10.3390/app12157734

Chicago/Turabian Style

Rebegea, Laura, Dorel Firescu, Gabriela Stoleriu, Manuela Arbune, Rodica Anghel, Mihaela Dumitru, Raul Mihailov, Anca Iulia Neagu, and Xenia Bacinschi. 2022. "Radiotherapy and Immunotherapy, Combined Treatment for Unresectable Mucosal Melanoma with Vaginal Origin" Applied Sciences 12, no. 15: 7734. https://doi.org/10.3390/app12157734

APA Style

Rebegea, L., Firescu, D., Stoleriu, G., Arbune, M., Anghel, R., Dumitru, M., Mihailov, R., Neagu, A. I., & Bacinschi, X. (2022). Radiotherapy and Immunotherapy, Combined Treatment for Unresectable Mucosal Melanoma with Vaginal Origin. Applied Sciences, 12(15), 7734. https://doi.org/10.3390/app12157734

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