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Bioengineered Skin Substitutes: Advances and Future Trends
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The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration

1
Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente (ICETA) da Universidade do Porto, Praça Gomes Teixeira, Apartado 55142, 4051-401 Porto, Portugal
2
Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, nº 228, 4050-313 Porto, Portugal
*
Author to whom correspondence should be addressed.
Bruna Lopes and Patrícia Sousa contributed equally to this work as first authors.
Academic Editor: Agnes Klar
Appl. Sci. 2021, 11(7), 3000; https://doi.org/10.3390/app11073000
Received: 2 March 2021 / Revised: 23 March 2021 / Accepted: 24 March 2021 / Published: 27 March 2021
(This article belongs to the Special Issue Skin Tissue Engineering)
In the past decades, regenerative medicine applied on skin lesions has been a field of constant improvement for both human and veterinary medicine. The process of healing cutaneous wound injuries implicates a well-organized cascade of molecular and biological processes. However, sometimes the normal process fails and can result in a chronic lesion. In addition, wounds are considered an increasing clinical impairment, due to the progressive ageing of the population, as well as the prevalence of concomitant diseases, such as diabetes and obesity, that represent risk-aggravating factors for the development of chronic skin lesions. Stem cells’ regenerative potential has been recognized worldwide, including towards skin lesion repair, Tissue engineering techniques have long been successfully associated with stem cell therapies, namely the application of three-dimensional (3D) bioprinted scaffolds. With this review, we intend to explore several stem cell sources with promising aptitude towards skin regeneration, as well as different techniques used to deliver those cells and provide a supporting extracellular matrix environment, with effective outcomes. Furthermore, different studies are discussed, both in vitro and in vivo, in terms of their relevance in the skin regeneration field. View Full-Text
Keywords: skin regeneration; wound healing; skin stem cells; skin vascularization; 3D printing skin regeneration; wound healing; skin stem cells; skin vascularization; 3D printing
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MDPI and ACS Style

Lopes, B.; Sousa, P.; Alvites, R.; Branquinho, M.; Sousa, A.; Mendonça, C.; Atayde, L.M.; Maurício, A.C. The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration. Appl. Sci. 2021, 11, 3000. https://doi.org/10.3390/app11073000

AMA Style

Lopes B, Sousa P, Alvites R, Branquinho M, Sousa A, Mendonça C, Atayde LM, Maurício AC. The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration. Applied Sciences. 2021; 11(7):3000. https://doi.org/10.3390/app11073000

Chicago/Turabian Style

Lopes, Bruna; Sousa, Patrícia; Alvites, Rui; Branquinho, Mariana; Sousa, Ana; Mendonça, Carla; Atayde, Luís M.; Maurício, Ana C. 2021. "The Application of Mesenchymal Stem Cells on Wound Repair and Regeneration" Appl. Sci. 11, no. 7: 3000. https://doi.org/10.3390/app11073000

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